PKS:Fung003

Polyketide Top

Species List

UniRef90 Class

UniRef50 Class

Gene Class

Domains (by CDD)

Domains (by MAPSI)

Exophiala dermatitidis (GenBank AAD31436) all species
Class	NRPKS (length: 2177) all classes   Class 11.NRPKS_I(4a)melanin in KS domain phylogeny	Reliability	putative
Product	melanin	GeneName	pks1(Wdpks1)
UniProt,UniRef90	[1] , [2]	UniRef50	[3]
Domain by MAPSI	(notation help / all patterns)
Domain by CDD	(notation help / all patterns)
Domain by ITER-DB	(notation help / all patterns)
Estimated Domain
Description	type I polyketide synthase [Exophiala dermatitidis]
Information	melanin, involved in dihydroxynaphthalene melanin biosynthesis. Inferred domain architecture: SAT-KS-AT-PT-ACP-ACP-TE/CLC
References	Ahuja M, Chiang YM, Chang SL, Praseuth MB, Entwistle R, Sanchez JF, Lo HC, Yeh HH, Oakley BR, Wang CC: Illuminating the diversity of aromatic polyketide synthases in aspergillus nidulans. J Am Chem Soc, 2012 Feng B, Wang X, Hauser M, Kaufmann S, Jentsch S, Haase G, Becker JM, Szaniszlo PJ: Molecular cloning and characterization of wdpks1, a gene involved in dihydroxynaphthalene melanin biosynthesis and virulence in wangiella (exophiala) dermatitidis. Infect Immun 69(3):1781-1794, 2001 Fisch KM, Gillaspy AF, Gipson M, Henrikson JC, Hoover AR, Jackson L, Najar FZ, Wagele H, Cichewicz RH: Chemical induction of silent biosynthetic pathway transcription in aspergillus niger. J Ind Microbiol Biotechnol 36(9):1199-1213, 2009 Li Y, Image, II, Xu W, Image I, Tang Y: Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem 285(30):22764-22773, 2010 Varga J, Rigo K, Kocsube S, Farkas B, Pal K: Diversity of polyketide synthase gene sequences in Aspergillus species. Res Microbiol 154:593-600, 2003
Link	AspGD

This work is performed by ShuHsi Lin (TW), Toshitaka Kumagai and Masanori Arita (JP)