PKS:Bact12

Polyketide Top

Species List

UniRef90 Class

UniRef50 Class

Gene Class

Domains (by CDD)

Domains (by MAPSI)

Lyngbya majuscula (GenBank AAT70106) all species
Class	RPKS (length: 2232) all classes   Class 07.Bacterial_PKS_mixed_species in KS domain phylogeny	Reliability	identified
Product	Curacin A	GeneName	curK
UniProt,UniRef90	[1] , [2]	UniRef50	[3]
Domain by MAPSI	KS-AT-DH-ER-KR-ACP (notation help / all patterns)
Domain by CDD	KS-AT-DH-ER-KR-PP (notation help / all patterns)
Domain by ITER-DB	{{{ITERDB}}} (notation help / all patterns)
Estimated Domain
Description	CurK [Lyngbya majuscula]
Information	One of proteins in Curacin A gene cluster. Domain composition is RPK. Final product is produced by NRPS-PKS.
References	Akey DL, Razelun JR, Tehranisa J, Sherman DH, Gerwick WH, Smith JL: Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway. Structure 18(1):94-105, 2010 Busche A, Gottstein D, Hein C, Ripin N, Pader I, Tufar P, Eisman EB, Gu L, Walsh CT, Sherman DH, Lohr F, Guntert P, Dotsch V: Characterization of molecular interactions between acp and halogenase domains in the curacin a polyketide synthase. ACS Chem Biol 7(2):378-386, 2012 Chang Z, Sitachitta N, Rossi JV, Roberts MA, Flatt PM, Jia J, Sherman DH,Gerwick WH: Biosynthetic pathway and gene cluster analysis of curacin a, an antitubulin natural product from the tropical marine cyanobacterium lyngbya majuscula. J Nat Prod 67(8):1356-1367, 2004 Schmitt I, Lumbsch HT: Ancient horizontal gene transfer from bacteria enhances biosynthetic capabilities of fungi. PLoS One 4:e4437, 2009
Link	AspGD

This work is performed by ShuHsi Lin (TW), Toshitaka Kumagai and Masanori Arita (JP)