PKS:An11g06460

Polyketide Top

Species List

UniRef90 Class

UniRef50 Class

Gene Class

Domains (by CDD)

Domains (by MAPSI)

Aspergillus niger CBS 513.88 (GenBank XP_001394625) all species
Class	PKS-NRPS (length: 3897) all classes   Class 33.NRPS-PKS_V in KS domain phylogeny	Reliability
Product		GeneName
UniProt,UniRef90	A2QWU2 , -	UniRef50	-
Domain by MAPSI	KS-AT-DH-KR-ACP (notation help / all patterns)
Domain by CDD	KS-AT-DH-KR-PP-Con-AMP(LuxE)-(PP)-KR (notation help / all patterns)
Domain by ITER-DB	{{{ITERDB}}} (notation help / all patterns)
Estimated Domain
Description	hypothetical protein An11g06460 [Aspergillus niger]
Information	Possible NRPS-PKS domain structure: KS-AT-DH-CAP.(Title: strong similarity to lovastatin nonaketide synthase lovB - Aspergillus terreus; Function: like fatty acids-polyketides are assembled by successive decarboxylative condensations of simple precursors.; Function: many polyketides are antibiotics.; Function: polyketide synthases catalyze the assembly of complex natural products from simple precursors such as propionyl-CoA and methylmalonyl-CoA in a biosynthetic process that closely parallels fatty acid biosynthesis.; Function: whereas the intermediates in fatty acid biosynthesis are fully reduced to generate unfunctionalized alkyl chains-the intermediates in polyketide biosynthesis may be only partially processed-giving rise to complex patterns of functional groups.; Remark: in A. terreus the genes involved in lovastatin biosynthesis are clustered; the structure of this cluster in A. terreus is very similar to what observed for the predicted ORFs cmln. 00. tfa_70cg-80wg and 90cg.; Remark: polyketide synthases are commercially valuable enzyme.; (2.3.1.-))
References	Pel HJ, de Winde JH, Archer DB, Dyer PS, Hofmann G, Schaap PJ, Turner G, de Vries RP, Albang R, Albermann K, Andersen MR, Bendtsen JD, Benen JA, van den Berg M, Breestraat S, Caddick MX, Contreras R, Cornell M, Coutinho PM, Danchin EG, Debets AJ, Dekker P, van Dijck PW, van Dijk A, Dijkhuizen L, Driessen AJ, d'Enfert C, Geysens S, Goosen C, Groot GS, de Groot PW, Guillemette T, Henrissat B, Herweijer M, van den Hombergh JP, van den Hondel CA, van der Heijden RT, van der Kaaij RM, Klis FM, Kools HJ, Kubicek CP, van Kuyk PA, Lauber J, Lu X, van der Maarel MJ, Meulenberg R, Menke H, Mortimer MA, Nielsen J, Oliver SG, Olsthoorn M, Pal K, van Peij NN, Ram AF, Rinas U, Roubos JA, Sagt CM, Schmoll M, Sun J, Ussery D, Varga J, Vervecken W, van de Vondervoort PJ, Wedler H, Wosten HA, Zeng AP, van Ooyen AJ, Visser J, Stam H: Genome sequencing and analysis of the versatile cell factory aspergillus niger cbs 513.88. Nat Biotechnol 25(2):221-231, 2007
Link	AspGD

This work is performed by ShuHsi Lin (TW), Toshitaka Kumagai and Masanori Arita (JP)