Enzyme:1.2.1.25

Basic Metabolism Top (代謝トップ)

Molecule Index (化合物索引)

EC classes ( EC分類)

Input New Data (新規入力)

Upper Levels: EC1.-.-.- Oxidoreductases. : EC1.2.-.- Acting on the aldehyde or oxo group of donors. : EC1.2.1.- With NAD(+) or NADP(+) as acceptor.

IDs and Links
IUBMB	EC1
ExPaSy	NiceZyme 1.2.1.25

3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase(CoA-methyl-propanoylating)
Systematic Name	3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase(CoA-methyl-propanoylating)
Common Name	2-oxoisovalerate dehydrogenase (acylating) alpha-ketoisovalerate dehydrogenase

NAD+ + CoA + 3-Methyl-2-oxo-butanoic acid = NADH + 2-Methyl-propanoyl-CoA + CO2 (links: = )

NAD+ <Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0 NADH 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32 CoA <Mapping> AtomMap:BMCCPUAPf023$BMFYB3CAa010$0 S- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] 2-methylpropanethioic acid 1 ↔ 6 2 ↔ 7 3 ↔ 8 4 ↔ 9 5 ↔ 10 6 ↔ 11 7 ↔ 12 8 ↔ 13 9 ↔ 14 10 ↔ 15 11 ↔ 16 12 ↔ 17 13 ↔ 18 14 ↔ 19 15 ↔ 20 32 ↔ 37 33 ↔ 38 34 ↔ 40 35 ↔ 39 36 ↔ 41 37 ↔ 42 38 ↔ 43 39 ↔ 44 40 ↔ 45 41 ↔ 46 42 ↔ 47 43 ↔ 48 44 ↔ 49 45 ↔ 50 3-Methyl-2-oxo-butanoic acid <Mapping> AtomMap:BMXXSX--0007$BMFYB4CAr010$0 CO2 1 ↔ 1 3-Methyl-2-oxo-butanoic acid <Mapping> AtomMap:BMFYB4CAr010$BMFYB3CAa010$0 S- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] 2-methylpropanethioic acid 2 ↔ 1 3 ↔ 2 4 ↔ 4 5 ↔ 3

NAD+ + CoA + 4-Methyl-2-oxo-pentanoic acid = NADH + 3-Methyl-butanoyl-CoA + CO2 (links: = )

NAD+ <Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0 NADH 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32 CoA <Mapping> AtomMap:BMCCPUAPf023$BMFYB4ESa006$0 S- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] 3-methylbutanethioic acid 1 ↔ 7 2 ↔ 8 3 ↔ 9 4 ↔ 10 5 ↔ 11 6 ↔ 12 7 ↔ 13 8 ↔ 14 9 ↔ 15 10 ↔ 16 11 ↔ 17 12 ↔ 18 13 ↔ 19 14 ↔ 20 15 ↔ 21 32 ↔ 38 33 ↔ 39 34 ↔ 40 35 ↔ 41 36 ↔ 42 37 ↔ 43 38 ↔ 44 39 ↔ 45 40 ↔ 46 41 ↔ 47 42 ↔ 48 43 ↔ 49 44 ↔ 50 45 ↔ 51 4-Methyl-2-oxo-pentanoic acid <Mapping> AtomMap:BMXXSX--0007$BMFYB4CAr013$0 CO2 1 ↔ 1 4-Methyl-2-oxo-pentanoic acid <Mapping> AtomMap:BMFYB4CAr013$BMFYB4ESa006$0 S- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] 3-methylbutanethioic acid 2 ↔ 1 3 ↔ 2 4 ↔ 3 5 ↔ 5 6 ↔ 4