PKS:Bact12

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Line 3: Line 3:
 
|species=Lyngbya majuscula
 
|species=Lyngbya majuscula
 
|taxonomy=Bacteria; Cyanobacteria; Oscillatoriales; Lyngbya
 
|taxonomy=Bacteria; Cyanobacteria; Oscillatoriales; Lyngbya
|product=jamaicamide
+
|product=Curacin A
 
|GenBank=AAT70106
 
|GenBank=AAT70106
 
|geneName=curK
 
|geneName=curK

Revision as of 03:28, 15 April 2012

Polyketide Top Species List UniRef90 Class UniRef50 Class Gene Class Domains
(by CDD)
Domains
(by MAPSI)
Lyngbya majuscula (GenBank AAT70106) all species
Class NRPS-PKS (length: 2232) all classes   Class 07.Bacterial_PKS_mixed_species in KS domain phylogeny Reliability putative
Product Curacin A GeneName curK
UniProt,UniRef90 [1] , [2] UniRef50 [3]
Domain by MAPSI KS-AT-DH-ER-KR-ACP

(notation help / all patterns)

Domain by CDD KS-AT-DH-ER-KR-PP

(notation help / all patterns)

Domain by ITER-DB {{{ITERDB}}}

(notation help / all patterns)

Estimated Domain
Description CurK [Lyngbya majuscula]
Information One of proteins in Curacin A gene cluster. Domain composition is RPK. Final product is produced by NRPS-PKS.
References
  • Akey DL, Razelun JR, Tehranisa J, Sherman DH, Gerwick WH, Smith JL: Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway. Structure 18(1):94-105, 2010
  • Busche A, Gottstein D, Hein C, Ripin N, Pader I, Tufar P, Eisman EB, Gu L, Walsh CT, Sherman DH, Lohr F, Guntert P, Dotsch V: Characterization of molecular interactions between acp and halogenase domains in the curacin a polyketide synthase. ACS Chem Biol 7(2):378-386, 2012
  • Chang Z, Sitachitta N, Rossi JV, Roberts MA, Flatt PM, Jia J, Sherman DH,Gerwick WH: Biosynthetic pathway and gene cluster analysis of curacin a, an antitubulin natural product from the tropical marine cyanobacterium lyngbya majuscula. J Nat Prod 67(8):1356-1367, 2004
  • Schmitt I, Lumbsch HT: Ancient horizontal gene transfer from bacteria enhances biosynthetic capabilities of fungi. PLoS One 4:e4437, 2009
Link AspGD

This work is performed by ShuHsi Lin (TW), Toshitaka Kumagai and Masanori Arita (JP)

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