PKS:Aspe07

Aspergillus westerdijkiae (GenBank [1]) all species
Class	(length: 5298) all classes Class in KS domain phylogeny	Reliability
Product		GeneName	aomsas
UniProt,UniRef90	[2] , [3]	UniRef50	[4]
Domain by MAPSI	(notation help / all patterns)
Domain by CDD	(notation help / all patterns)
Domain by ITER-DB	{{{ITERDB}}} (notation help / all patterns)
Estimated Domain
Description
Information	The predicted amino acid sequence of aomsas shows an identity of 40–56% with different methylsalicylic acid synthase genes found in Byssochlamys nivea, P. patulum, A. terreus and Streptomyces viridochromogenes. An aomsas knockout mutant “aoΔmsas” of A. westerdijkiae, not only lost the capacity to produce isoasperlactone and asperlactone, but also 6-methylsalicylic acid. The genetically complemented mutant ao+msas restored the biosynthesis of all the missing metabolites.
References	Bacha N, Dao HP, Atoui A, Mathieu F, O'Callaghan J, Puel O, Liboz T, Dobson AD, Lebrihi A: Cloning and characterization of novel methylsalicylic acid synthase gene involved in the biosynthesis of isoasperlactone and asperlactone in aspergillus westerdijkiae. Fungal Genet Biol 46(10):742-749, 2009
Link	AspGD

This work is performed by ShuHsi Lin (TW), Toshitaka Kumagai and Masanori Arita (JP)