| Exophiala dermatitidis (GenBank AAD31436) all species
|
| Class
|
NRPKS (length: 2177) all classes Class 11.NRPKS_I(4a)melanin in KS domain phylogeny
|
Reliability
|
putative
|
| Product
|
melanin
|
GeneName
|
pks1(Wdpks1)
|
| UniProt,UniRef90
|
[1] , [2]
|
UniRef50
|
[3]
|
| Domain by MAPSI
|
KS-AT-ACP-ACP-CYC
(notation help / all patterns)
|
| Domain by CDD
|
KS-AT-PP-PP-TE
(notation help / all patterns)
|
| Domain by ITER-DB
|
{{{ITERDB}}}
(notation help / all patterns)
|
| Estimated Domain
|
|
| Description
|
type I polyketide synthase [Exophiala dermatitidis]
|
| Information
|
melanin, involved in dihydroxynaphthalene melanin biosynthesis. Inferred domain architecture: SAT-KS-AT-PT-ACP-ACP-TE/CLC
|
| References
|
- Ahuja M, Chiang YM, Chang SL, Praseuth MB, Entwistle R, Sanchez JF, Lo HC, Yeh HH, Oakley BR, Wang CC: Illuminating the diversity of aromatic polyketide synthases in aspergillus nidulans. J Am Chem Soc, 2012
- Feng B, Wang X, Hauser M, Kaufmann S, Jentsch S, Haase G, Becker JM, Szaniszlo PJ: Molecular cloning and characterization of wdpks1, a gene involved in dihydroxynaphthalene melanin biosynthesis and virulence in wangiella (exophiala) dermatitidis. Infect Immun 69(3):1781-1794, 2001
- Fisch KM, Gillaspy AF, Gipson M, Henrikson JC, Hoover AR, Jackson L, Najar FZ, Wagele H, Cichewicz RH: Chemical induction of silent biosynthetic pathway transcription in aspergillus niger. J Ind Microbiol Biotechnol 36(9):1199-1213, 2009
- Li Y, Image, II, Xu W, Image I, Tang Y: Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem 285(30):22764-22773, 2010
- Varga J, Rigo K, Kocsube S, Farkas B, Pal K: Diversity of polyketide synthase gene sequences in Aspergillus species. Res Microbiol 154:593-600, 2003
|
| Link
|
AspGD
|
This work is performed by ShuHsi Lin (TW), Toshitaka Kumagai and Masanori Arita (JP)
