Category:TP3
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{| style="text-align:center" | {| style="text-align:center" | ||
| − | | [[Image:5alpha-steroid.png]] || [[Image:5beta-steroid.png]] | + | | [[Image:cholestane.png]] || [[Image:5alpha-steroid.png]] || [[Image:5beta-steroid.png]] |
|- | |- | ||
| + | | cholestane backbone | ||
| 5α-configuration | | 5α-configuration | ||
| 5β-configuration | | 5β-configuration | ||
|} | |} | ||
</center> | </center> | ||
| − | |||
==Design of Tri-terpene ID numbers ID番号の設計== | ==Design of Tri-terpene ID numbers ID番号の設計== | ||
Revision as of 15:18, 3 August 2010
Contents |
Triterpene (C30) Classes
Biosynthesis
Triterpenes are formed by joining two FPPs tail-to-tail. The precursor compound of cholesterol (C27) is lanosterol (C30) for animals. For plants, fungi and algae, it is almost cycloartenol with a trace of lanosterol-derived sterols[1].
Ring configuration
The basic structure is 4 carbon rings, cyclopenta[a]phenanthrene, gonane, or sterane. The rings B/C are always trans in all natural steroids. If the rings C/D are trans, it is called gonane. If its stereochemistry is unspecified, it is called sterane. Most steroids take gonane form, but in cardenolides and bufanolides, the rings C/D are cis.
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| Cyclopenta[a]phenanthrene | Gonane |
The majority of steroids have methyl groups sticking out from the bridgehead positions C-10 and C-13. When these methyl groups (or hydrogens) stand above the plane, they are called β-configuration. Those below the plane are called α-configuration. If the configuration at any site is unknown, it is indicated as ξ (Greek Xi). By default, hydrogen atoms or substituents at the positions C-8, 9, 10, 13, and 14 are assumed to be 8β, 9α, 10β, 13β, and 14α configurations. C-5 is a special position, because there are as many 5α steroids as 5β are.
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| cholestane backbone | 5α-configuration | 5β-configuration |
Design of Tri-terpene ID numbers ID番号の設計
12-DIGIT
| T | P | 3 | x | y | y | r | h | g | n | c | c |
- x ... species information
| Symbol at x | Kingdom | Phyla | Examples |
|---|---|---|---|
| I | Animalia | Arthropoda (Insects, crabs) | ecdysteroids |
| V | Chordate (Vertebrates) | sex steroids, corticosteroids, anabolic steroids | |
| O | Others | marine steroids | |
| P | Plantae | Phytosterols | lanosterols, cholesterols, brassinolides |
| S | Saponins | saponins | |
| F | Fungi | ergosterols | ergosterols |
| B | Bacteria | bacterial sterols | hopanoids |
- y ... backbone structure (母核構造)
|
|
- r ... number of major rings (環構造数)
Click above categories to see details.
- h ... hydroxylation pattern (水酸基数)
Click above categories to see details.
- g ... glycosylation pattern(糖修飾パターン)
Click above categories to see details.
- n ... number of sugars (修飾糖数)
Click above categories to see details.
- c ... serial number (通し番号)
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