PKS:AN8383

Polyketide Top

Species List

UniRef90 Class

UniRef50 Class

Gene Class

Domains (by CDD)

Domains (by MAPSI)

Aspergillus nidulans FGSC A4 (GenBank XP_681652) all species
Class	PRPKS (length: 2476) all classes   Class in KS domain phylogeny	Reliability	Verified
Product	austinol, dehydroaustinol	GeneName	pks11(ausA)
UniProt,UniRef90	C8VE81 , C8VE81	UniRef50	C8VE81
Domain by MAPSI	KS-AT-ACP (notation help / all patterns)
Domain by CDD	KS-AT-(DH)-PP-ME-(Aes/EL) (notation help / all patterns)
Domain by ITER-DB	KS-AT-ACP (notation help / all patterns)
Estimated Domain	SAT-KS-AT-PT-ACP-ME-TE
Description
Information	Other accession number: CBF80428, EAA67005. Different with ANIA 00523(XP_658127). DH and Aes/EL domain from CDD are incomplete. ANIA08383 is possibly classified into NRPKS. Predicted gene cluster:7 genes; known gene cluster: 4 genes.
References	Ahuja M, Chiang YM, Chang SL, Praseuth MB, Entwistle R, Sanchez JF, Lo HC, Yeh HH, Oakley BR, Wang CC: Illuminating the diversity of aromatic polyketide synthases in aspergillus nidulans. J Am Chem Soc, 2012 Andersen M R, Nielsen J B, Klitgaard A, Petersen L M, Zachariasen M, Hansen T J, Blicher L H, Gotfredsen C H, Larsen T O, Nielsen K F, Mortensen U H: Accurate prediction of secondary metabolite gene clusters in filamentous fungi. Proc Natl Acad Sci U S A 110(1): E99-107. 2013 Lo HC, Entwistle R, Guo CJ, Ahuja M, Szewczyk E, Hung JH, Chiang YM, Oakley BR, Wang CC: Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in aspergillus nidulans. J Am Chem Soc 134(10):4709-4720, 2012 Schmitt I, Kautz S, Lumbsch HT: 6-MSAS-like polyketide synthase genes occur in lichenized ascomycetes. Mycol Res 112:289-296, 2008
Link	AspGD

This work is performed by ShuHsi Lin (TW), Toshitaka Kumagai and Masanori Arita (JP)