Template:ECHierarchy

1.-.-.-  Oxidoreductases.
1.1.-.-   Acting on the CH-OH group of donors.
1.1.1.-    With NAD(+) or NADP(+) as acceptor.
1.1.2.-    With a cytochrome as acceptor.
1.1.3.-    With oxygen as acceptor.
1.1.4.-    With a disulfide as acceptor.
1.1.5.-    With a quinone or similar compound as acceptor.
1.1.99.-    With other acceptors.
1.2.-.-   Acting on the aldehyde or oxo group of donors.
1.2.1.-    With NAD(+) or NADP(+) as acceptor.
1.2.2.-    With a cytochrome as acceptor.
1.2.3.-    With oxygen as acceptor.
1.2.4.-    With a disulfide as acceptor.
1.2.7.-    With an iron-sulfur protein as acceptor.
1.2.99.-    With other acceptors.
1.3.-.-   Acting on the CH-CH group of donors.
1.3.1.-    With NAD(+) or NADP(+) as acceptor.
1.3.2.-    With a cytochrome as acceptor.
1.3.3.-    With oxygen as acceptor.
1.3.5.-    With a quinone or related compound as acceptor.
1.3.7.-    With an iron-sulfur protein as acceptor.
1.3.99.-    With other acceptors.
1.4.-.-   Acting on the CH-NH(2) group of donors.
1.4.1.-    With NAD(+) or NADP(+) as acceptor.
1.4.2.-    With a cytochrome as acceptor.
1.4.3.-    With oxygen as acceptor.
1.4.4.-    With a disulfide as acceptor.
1.4.7.-    With an iron-sulfur protein as acceptor.
1.4.99.-    With other acceptors.
1.5.-.-   Acting on the CH-NH group of donors.
1.5.1.-    With NAD(+) or NADP(+) as acceptor.
1.5.3.-    With oxygen as acceptor.
1.5.4.-    With a disulfide as acceptor.
1.5.5.-    With a quinone or similar compound as acceptor.
1.5.7.-    With an iron-sulfur protein as acceptor.
1.5.8.-    With a flavin as acceptor.
1.5.99.-    With other acceptors.
1.6.-.-   Acting on NADH or NADPH.
1.6.1.-    With NAD(+) or NADP(+) as acceptor.
1.6.2.-    With a heme protein as acceptor.
1.6.3.-    With a oxygen as acceptor.
1.6.5.-    With a quinone or similar compound as acceptor.
1.6.6.-    With a nitrogenous group as acceptor.
1.6.99.-    With other acceptors.
1.7.-.-   Acting on other nitrogenous compounds as donors.
1.7.1.-    With NAD(+) or NADP(+) as acceptor.
1.7.2.-    With a cytochrome as acceptor.
1.7.3.-    With oxygen as acceptor.
1.7.7.-    With an iron-sulfur protein as acceptor.
1.7.99.-    With other acceptors.
1.8.-.-   Acting on a sulfur group of donors.
1.8.1.-    With NAD(+) or NADP(+) as acceptor.
1.8.2.-    With a cytochrome as acceptor.
1.8.3.-    With oxygen as acceptor.
1.8.4.-    With a disulfide as acceptor.
1.8.5.-    With a quinone or similar compound as acceptor.
1.8.7.-    With an iron-sulfur protein as acceptor.
1.8.98.-    With other, known, acceptors.
1.8.99.-    With other acceptors.
1.9.-.-   Acting on a heme group of donors.
1.9.3.-    With oxygen as acceptor.
1.9.6.-    With a nitrogenous group as acceptor.
1.9.99.-    With other acceptors.
1.10.-.-   Acting on diphenols and related substances as donors.
1.10.1.-    With NAD(+) or NADP(+) as acceptor.
1.10.2.-    With a cytochrome as acceptor.
1.10.3.-    With oxygen as acceptor.
1.10.99.-    With other acceptors.
1.11.-.-   Acting on a peroxide as acceptor.
1.11.1.-    Peroxidases.
1.12.-.-   Acting on hydrogen as donor.
1.12.1.-    With NAD(+) or NADP(+) as acceptor.
1.12.2.-    With a cytochrome as acceptor.
1.12.5.-    With a quinone or similar compound as acceptor.
1.12.7.-    With an iron-sulfur protein as acceptor.
1.12.98.-    With other known acceptors.
1.12.99.-    With other acceptors.
1.13.-.-   Acting on single donors with incorporation of molecular oxygen.
1.13.11.-    With incorporation of two atoms of oxygen.
1.13.12.-    With incorporation of one atom of oxygen.
1.13.99.-    Miscellaneous (requires further characterization).
1.14.-.-   Acting on paired donors, with incorporation or reduction of
1.14.11.-    With 2-oxoglutarate as one donor, and incorporation of one
1.14.12.-    With NADH or NADPH as one donor, and incorporation of two
1.14.13.-    With NADH or NADPH as one donor, and incorporation of one atom
1.14.14.-    With reduced flavin or flavoprotein as one donor, and
1.14.15.-    With a reduced iron-sulfur protein as one donor, and
1.14.16.-    With reduced pteridine as one donor, and incorporation of one
1.14.17.-    With reduced ascorbate as one donor, and incorporation of one
1.14.18.-    With another compound as one donor, and incorporation of one
1.14.19.-    With oxidation of a pair of donors resulting in the reduction
1.14.20.-    With 2-oxoglutarate as one donor, and the other dehydrogenated.
1.14.21.-    With NADH or NADPH as one donor, and the other dehydrogenated.
1.14.99.-    Miscellaneous (requires further characterization).
1.15.-.-   Acting on superoxide as acceptor.
1.15.1.-    Acting on superoxide as acceptor.
1.16.-.-   Oxidizing metal ions.
1.16.1.-    With NAD(+) or NADP(+) as acceptor.
1.16.3.-    With oxygen as acceptor.
1.16.8.-    With flavin as acceptor.
1.17.-.-   Acting on CH or CH(2) groups.
1.17.1.-    With NAD(+) or NADP(+) as acceptor.
1.17.3.-    With oxygen as acceptor.
1.17.4.-    With a disulfide as acceptor.
1.17.5.-    With a quinone or similar compound as acceptor.
1.17.99.-    With other acceptors.
1.18.-.-   Acting on iron-sulfur proteins as donors.
1.18.1.-    With NAD(+) or NADP(+) as acceptor.
1.18.6.-    With dinitrogen as acceptor.
1.19.-.-   Acting on reduced flavodoxin as donor.
1.19.6.-    With dinitrogen as acceptor.
1.20.-.-   Acting on phosphorus or arsenic in donors.
1.20.1.-    Acting on phosphorus or arsenic in donors, with NAD(P)(+) as
1.20.4.-    Acting on phosphorus or arsenic in donors, with disulfide as
1.20.98.-    Acting on phosphorus or arsenic in donors, with other, known
1.20.99.-    Acting on phosphorus or arsenic in donors, with other
1.21.-.-   Acting on x-H and y-H to form an x-y bond.
1.21.3.-    With oxygen as acceptor.
1.21.4.-    With a disulfide as acceptor.
1.21.99.-    With other acceptors.
1.97.-.-   Other oxidoreductases.
1.97.1.-    Sole sub-subclass for oxidoreductases that do not belong in the

2.-.-.-  Transferases.
2.1.-.-   Transferring one-carbon groups.
2.1.1.-    Methyltransferases.
2.1.2.-    Hydroxymethyl-, formyl- and related transferases.
2.1.3.-    Carboxyl- and carbamoyltransferases.
2.1.4.-    Amidinotransferases.
2.2.-.-   Transferring aldehyde or ketone residues.
2.2.1.-    Transketolases and transaldolases.
2.3.-.-   Acyltransferases.
2.3.1.-    Transferring groups other than amino-acyl groups.
2.3.2.-    Aminoacyltransferases.
2.3.3.-    Acyl groups converted into alkyl on transfer.
2.4.-.-   Glycosyltransferases.
2.4.1.-    Hexosyltransferases.
2.4.2.-    Pentosyltransferases.
2.4.99.-    Transferring other glycosyl groups.
2.5.-.-   Transferring alkyl or aryl groups, other than methyl groups.
2.5.1.-    Transferring alkyl or aryl groups, other than methyl groups.
2.6.-.-   Transferring nitrogenous groups.
2.6.1.-    Transaminases (aminotransferases).
2.6.3.-    Oximinotransferases.
2.6.99.-    Transferring other nitrogenous groups.
2.7.-.-   Transferring phosphorous-containing groups.
2.7.1.-    Phosphotransferases with an alcohol group as acceptor.
2.7.2.-    Phosphotransferases with a carboxyl group as acceptor.
2.7.3.-    Phosphotransferases with a nitrogenous group as acceptor.
2.7.4.-    Phosphotransferases with a phosphate group as acceptor.
2.7.6.-    Diphosphotransferases.
2.7.7.-    Nucleotidyltransferases.
2.7.8.-    Transferases for other substituted phosphate groups.
2.7.9.-    Phosphotransferases with paired acceptors.
2.7.10.-    Protein-tyrosine kinases.
2.7.11.-    Protein-serine/threonine kinases.
2.7.12.-    Dual-specificity kinases (those acting on Ser/Thr and Tyr
2.7.13.-    Protein-histidine kinases.
2.7.99.-    Other protein kinases.
2.8.-.-   Transferring sulfur-containing groups.
2.8.1.-    Sulfurtransferases.
2.8.2.-    Sulfotransferases.
2.8.3.-    CoA-transferases.
2.8.4.-    Transferring alkylthio groups.
2.9.-.-   Transferring selenium-containing groups.
2.9.1.-    Selenotransferases.

3.-.-.-  Hydrolases.
3.1.-.-   Acting on ester bonds.
3.1.1.-    Carboxylic ester hydrolases.
3.1.2.-    Thiolester hydrolases.
3.1.3.-    Phosphoric monoester hydrolases.
3.1.4.-    Phosphoric diester hydrolases.
3.1.5.-    Triphosphoric monoester hydrolases.
3.1.6.-    Sulfuric ester hydrolases.
3.1.7.-    Diphosphoric monoester hydrolases.
3.1.8.-    Phosphoric triester hydrolases.
3.1.11.-    Exodeoxyribonucleases producing 5'-phosphomonoesters.
3.1.13.-    Exoribonucleases producing 5'-phosphomonoesters.
3.1.14.-    Exoribonucleases producing 3'-phosphomonoesters.
3.1.15.-    Exonucleases active with either ribo- or deoxyribonucleic acid
3.1.16.-    Exonucleases active with either ribo- or deoxyribonucleic acid
3.1.21.-    Endodeoxyribonucleases producing 5'-phosphomonoesters.
3.1.22.-    Endodeoxyribonucleases producing other than 5'-phosphomonoesters.
3.1.25.-    Site-specific endodeoxyribonucleases specific for altered bases.
3.1.26.-    Endoribonucleases producing 5'-phosphomonoesters.
3.1.27.-    Endoribonucleases producing other than 5'-phosphomonoesters.
3.1.30.-    Endoribonucleases active with either ribo- or deoxyribonucleic
3.1.31.-    Endoribonucleases active with either ribo- or deoxyribonucleic
3.2.-.-   Glycosylases.
3.2.1.-    Glycosidases, i.e.enzymes hydrolyzing O- and S-glycosyl
3.2.2.-    Hydrolyzing N-glycosyl compounds.
3.3.-.-   Acting on ether bonds.
3.3.1.-    Thioether and trialkylsulfonium hydrolases.
3.3.2.-    Ether hydrolases.
3.4.-.-   Acting on peptide bonds (peptide hydrolases).
3.4.11.-    Aminopeptidases.
3.4.13.-    Dipeptidases.
3.4.14.-    Dipeptidyl-peptidases and tripeptidyl-peptidases.
3.4.15.-    Peptidyl-dipeptidases.
3.4.16.-    Serine-type carboxypeptidases.
3.4.17.-    Metallocarboxypeptidases.
3.4.18.-    Cysteine-type carboxypeptidases.
3.4.19.-    Omega peptidases.
3.4.21.-    Serine endopeptidases.
3.4.22.-    Cysteine endopeptidases.
3.4.23.-    Aspartic endopeptidases.
3.4.24.-    Metalloendopeptidases.
3.4.25.-    Threonine endopeptidases.
3.4.99.-    Endopeptidases of unknown catalytic mechanism.
3.5.-.-   Acting on carbon-nitrogen bonds, other than peptide bonds.
3.5.1.-    In linear amides.
3.5.2.-    In cyclic amides.
3.5.3.-    In linear amidines.
3.5.4.-    In cyclic amidines.
3.5.5.-    In nitriles.
3.5.99.-    In other compounds.
3.6.-.-   Acting on acid anhydrides.
3.6.1.-    In phosphorous-containing anhydrides.
3.6.2.-    In sulfonyl-containing anhydrides.
3.6.3.-    Acting on acid anhydrides; catalyzing transmembrane movement
3.6.4.-    Acting on acid anhydrides; involved in cellular and
3.6.5.-    Acting on GTP; involved in cellular and subcellular movement.
3.7.-.-   Acting on carbon-carbon bonds.
3.7.1.-    In ketonic substances.
3.8.-.-   Acting on halide bonds.
3.8.1.-    In C-halide compounds.
3.9.-.-   Acting on phosphorus-nitrogen bonds.
3.9.1.-    Acting on phosphorus-nitrogen bonds.
3.10.-.-   Acting on sulfur-nitrogen bonds.
3.10.1.-    Acting on sulfur-nitrogen bonds.
3.11.-.-   Acting on carbon-phosphorus bonds.
3.11.1.-    Acting on carbon-phosphorus bonds.
3.12.-.-   Acting on sulfur-sulfur bonds.
3.12.1.-    Acting on sulfur-sulfur bonds.
3.13.-.-   Acting on carbon-sulfur bonds.
3.13.1.-    Acting on carbon-sulfur bonds.

4.-.-.-  Lyases.
4.1.-.-   Carbon-carbon lyases.
4.1.1.-    Carboxy-lyases.
4.1.2.-    Aldehyde-lyases.
4.1.3.-    Oxo-acid-lyases.
4.1.99.-    Other carbon-carbon lyases.
4.2.-.-   Carbon-oxygen lyases.
4.2.1.-    Hydro-lyases.
4.2.2.-    Acting on polysaccharides.
4.2.3.-    Acting on phosphates.
4.2.99.-    Other carbon-oxygen lyases.
4.3.-.-   Carbon-nitrogen lyases.
4.3.1.-    Ammonia-lyases.
4.3.2.-    Lyases acting on amides, amidines, etc.
4.3.3.-    Amine-lyases.
4.4.-.-   Carbon-sulfur lyases.
4.4.1.-    Carbon-sulfur lyases.
4.5.-.-   Carbon-halide lyases.
4.5.1.-    Carbon-halide lyases.
4.6.-.-   Phosphorus-oxygen lyases.
4.6.1.-    Phosphorus-oxygen lyases.
4.99.-.-   Other lyases.
4.99.1.-    Sole sub-subclass for lyases that do not belong in the other

5.-.-.-  Isomerases.
5.1.-.-   Racemases and epimerases.
5.1.1.-    Acting on amino acids and derivatives.
5.1.2.-    Acting on hydroxy acids and derivatives.
5.1.3.-    Acting on carbohydrates and derivatives.
5.1.99.-    Acting on other compounds.
5.2.-.-   Cis-trans-isomerases.
5.2.1.-    Cis-trans Isomerases.
5.3.-.-   Intramolecular oxidoreductases.
5.3.1.-    Interconverting aldoses and ketoses.
5.3.2.-    Interconverting keto- and enol- groups.
5.3.3.-    Transposing C==C bonds.
5.3.4.-    Transposing S-S bonds.
5.3.99.-    Other intramolecular oxidoreductases.
5.4.-.-   Intramolecular transferases (mutases).
5.4.1.-    Transferring acyl groups.
5.4.2.-    Phosphotransferases (phosphomutases).
5.4.3.-    Transferring amino groups.
5.4.4.-    Transferring hydroxy groups.
5.4.99.-    Transferring other groups.
5.5.-.-   Intramolecular lyases.
5.5.1.-    Intramolecular lyases.
5.99.-.-   Other isomerases.
5.99.1.-    Sole sub-subclass for isomerases that do not belong in the other

6.-.-.-  Ligases.
6.1.-.-   Forming carbon-oxygen bonds.
6.1.1.-    Ligases forming aminoacyl-tRNA and related compounds.
6.2.-.-   Forming carbon-sulfur bonds.
6.2.1.-    Acid--thiol ligases.
6.3.-.-   Forming carbon-nitrogen bonds.
6.3.1.-    Acid--ammonia (or amide) ligases (amide synthases).
6.3.2.-    Acid--D-amino-acid ligases (peptide synthases).
6.3.3.-    Cyclo-ligases.
6.3.4.-    Other carbon--nitrogen ligases.
6.3.5.-    Carbon--nitrogen ligases with glutamine as amido-N-donor.
6.4.-.-   Forming carbon-carbon bonds.
6.4.1.-    Ligases that form carbon-carbon bonds.
6.5.-.-   Forming phosphoric ester bonds.
6.5.1.-    Ligases that form phosphoric-ester bonds.
6.6.-.-   Forming nitrogen-metal bonds.
6.6.1.-    Forming coordination complexes.

Upper Levels: EC{{{ec}}} [[]] : EC{{{ec}}}. [[]] : EC{{{ec}}}.. [[]]