PKS:Bact36

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|species=Saccharopolyspora erythraea NRRL 2338
 
|species=Saccharopolyspora erythraea NRRL 2338
 
|taxonomy=Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Pseudonocardineae; Pseudonocardiaceae; Saccharopolyspora
 
|taxonomy=Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Pseudonocardineae; Pseudonocardiaceae; Saccharopolyspora
|product=
+
|product=Mellein
 
|GenBank=YP_001107644
 
|GenBank=YP_001107644
|geneName=
+
|geneName=pks8
 
|MAPSI=KS-AT-DH-KR-ACP
 
|MAPSI=KS-AT-DH-KR-ACP
 
|CDD=KS-AT-DH-KR-PP
 
|CDD=KS-AT-DH-KR-PP
 +
|InferredDomain=KS-AT-TH-KR-ACP
 
|class=iPKS-6-MSAS
 
|class=iPKS-6-MSAS
|reliability=putative
+
|reliability=identified
 
|description=iterative type I polyketide synthase [Saccharopolyspora erythraea NRRL 2338]
 
|description=iterative type I polyketide synthase [Saccharopolyspora erythraea NRRL 2338]
|information=
+
|information=SACE5532 (or pks8) catalyzes the formation of Mellein (3,4-dihydro-8-hydroxy-3-methylisocoumarin, 1). Notably, the KR domain alone is able to recognize and differentiate the polyketide intermediates.
 
|length=1738
 
|length=1738
 +
|references=\*Schmitt.+2009$~\*Oliynyk.+2007$~\*Sun H.+2012$
 
}}
 
}}
 
{{{{NAMESPACE}}/Footer}}
 
{{{{NAMESPACE}}/Footer}}

Latest revision as of 03:02, 14 September 2012

Polyketide Top Species List UniRef90 Class UniRef50 Class Gene Class Domains
(by CDD)
Domains
(by MAPSI)
Saccharopolyspora erythraea NRRL 2338 (GenBank YP_001107644) all species
Class iPKS-6-MSAS (length: 1738) all classes   Class 03b_bMSAS in KS domain phylogeny Reliability identified
Product Mellein GeneName pks8
UniProt,UniRef90 [1] , [2] UniRef50 [3]
Domain by MAPSI KS-AT-DH-KR-ACP

(notation help / all patterns)

Domain by CDD KS-AT-DH-KR-PP

(notation help / all patterns)

Domain by ITER-DB {{{ITERDB}}}

(notation help / all patterns)

Estimated Domain KS-AT-TH-KR-ACP
Description iterative type I polyketide synthase [Saccharopolyspora erythraea NRRL 2338]
Information SACE5532 (or pks8) catalyzes the formation of Mellein (3,4-dihydro-8-hydroxy-3-methylisocoumarin, 1). Notably, the KR domain alone is able to recognize and differentiate the polyketide intermediates.
References
  • Oliynyk M, Samborskyy M, Lester JB, Mironenko T, Scott N, Dickens S, Haydock SF and Leadlay PF: Complete genome sequence of the erythromycin-producing bacterium saccharopolyspora erythraea nrrl23338. Nat Biotechnol 25(4):447-453, 2007
  • Schmitt I, Lumbsch HT: Ancient horizontal gene transfer from bacteria enhances biosynthetic capabilities of fungi. PLoS One 4:e4437, 2009
  • Sun H, Ho CL, Ding F, Soehano I, Liu XW and Liang ZX: Synthesis of (r)-mellein by a partially reducing iterative polyketide synthase. J Am Chem Soc 134(29):11924-11927, 2012
Link AspGD

This work is performed by ShuHsi Lin (TW), Toshitaka Kumagai and Masanori Arita (JP)

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