PKS:Afu2g17600

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|InferredDomain=SAT-KS-AT-PT-ACP-ACP-TE/CLC
 
|InferredDomain=SAT-KS-AT-PT-ACP-ACP-TE/CLC
 
|class=NRPKS
 
|class=NRPKS
−
|reliability=putative
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|reliability=verified
 
|description=Conidial pigment polyketide synthase PksP/Alb1 [Aspergillus fumigatus Af293].Polyketide synthase involved in biosynthesis of the conidial pigment; controlled in part by the cAMP/protein kinase A (PKA) signal transduction pathway; mutants fail to inhibit phagolysosome acidification
 
|description=Conidial pigment polyketide synthase PksP/Alb1 [Aspergillus fumigatus Af293].Polyketide synthase involved in biosynthesis of the conidial pigment; controlled in part by the cAMP/protein kinase A (PKA) signal transduction pathway; mutants fail to inhibit phagolysosome acidification
 
|information=
 
|information=
 
|length=2146
 
|length=2146
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|references=\*Li.+2010$~\*Ahuja.+2012$~\*Thywissen.+2011$
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|references=\*Langfelder.+1998$~\*Li.+2010$~\*Ahuja.+2012$~\*Thywissen.+2011$
 
}}
 
}}
 
{{{{NAMESPACE}}/Footer}}
 
{{{{NAMESPACE}}/Footer}}

Latest revision as of 16:02, 2 April 2013

Polyketide Top Species List UniRef90 Class UniRef50 Class Gene Class Domains
(by CDD) 		Domains
(by MAPSI)
Aspergillus fumigatus Af293 (GenBank XP_756095) all species
Class NRPKS (length: 2146) all classes   Class in KS domain phylogeny Reliability verified
Product YWA1(conidial pigment) GeneName pksP(alb1)
UniProt,UniRef90 Q4WZA8 , Q4WZA8 UniRef50 Q03149
Domain by MAPSI KS-AT-ACP-ACP-CYC

(notation help / all patterns)

Domain by CDD KS-AT-PP-PP-TE

(notation help / all patterns)

Domain by ITER-DB KS-AT-ACP-ACP-CYC

(notation help / all patterns)

Estimated Domain SAT-KS-AT-PT-ACP-ACP-TE/CLC
Description Conidial pigment polyketide synthase PksP/Alb1 [Aspergillus fumigatus Af293].Polyketide synthase involved in biosynthesis of the conidial pigment; controlled in part by the cAMP/protein kinase A (PKA) signal transduction pathway; mutants fail to inhibit phagolysosome acidification
Information
References
  • Ahuja M, Chiang YM, Chang SL, Praseuth MB, Entwistle R, Sanchez JF, Lo HC, Yeh HH, Oakley BR, Wang CC: Illuminating the diversity of aromatic polyketide synthases in aspergillus nidulans. J Am Chem Soc, 2012
  • Langfelder K, Jahn B, Gehringer H, Schmidt A, Wanner G and Brakhage AA: Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence. Med Microbiol Immunol 187(2): 79-89. 1998
  • Li Y, Image, II, Xu W, Image I, Tang Y: Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem 285(30):22764-22773, 2010
  • Thywissen A, Heinekamp T, Dahse HM, Schmaler-Ripcke J, Nietzsche S, Zipfel PF, Brakhage AA: Conidial dihydroxynaphthalene melanin of the human pathogenic fungus aspergillus fumigatus interferes with the host endocytosis pathway. Frontiers in microbiology 296, 2011
Link AspGD

This work is performed by ShuHsi Lin (TW), Toshitaka Kumagai and Masanori Arita (JP)

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