Enzyme:2.3.1.85

Revision as of 09:00, 2 February 2009

acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-and enoyl-reducing and thioester-hydrolysing)
Systematic Name	acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-and enoyl-reducing and thioester-hydrolysing)
Common Name	fatty-acid synthase yeast fatty acid synthase

NADP+	<Mapping> AtomMap:BMCCPUAPt033$BMCCPUAPt034$0	NADPH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

NADP+	<Mapping> AtomMap:BMCCPUAPt033$BMCCPUAPt034$0	NADPH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

CoA	<Mapping> AtomMap:BMCCPUAPf023$BMFYS2ESa001$0	S- [2- [3- [ [ (2R) -4- [ [ [ (2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] ethanethioate
	1 ↔ 4 2 ↔ 5 3 ↔ 6 4 ↔ 7 5 ↔ 8 6 ↔ 9 7 ↔ 10 8 ↔ 11 9 ↔ 12 10 ↔ 13 11 ↔ 14 12 ↔ 15 13 ↔ 16 14 ↔ 17 15 ↔ 18 32 ↔ 35 33 ↔ 36 34 ↔ 38 35 ↔ 37 36 ↔ 39 37 ↔ 40 38 ↔ 41 39 ↔ 42 40 ↔ 43 41 ↔ 44 42 ↔ 45 43 ↔ 46 44 ↔ 47 45 ↔ 48

Malonyl-CoA	<Mapping> AtomMap:BMFYS3CAa020$BMCCPUAPf023$0	CoA
	7 ↔ 1 8 ↔ 2 9 ↔ 3 10 ↔ 4 11 ↔ 5 12 ↔ 6 13 ↔ 7 14 ↔ 8 15 ↔ 9 16 ↔ 10 17 ↔ 11 18 ↔ 12 19 ↔ 13 20 ↔ 14 21 ↔ 15 38 ↔ 32 39 ↔ 33 40 ↔ 35 41 ↔ 34 42 ↔ 36 43 ↔ 37 44 ↔ 38 45 ↔ 39 46 ↔ 40 47 ↔ 41 48 ↔ 42 49 ↔ 43 50 ↔ 44 51 ↔ 45

CO2	<Mapping> AtomMap:BMXXSX--0007$BMFYS3CAa020$0	Malonyl-CoA
	1 ↔ 1

Malonyl-CoA	<Mapping> AtomMap:BMFYS3CAa020$BMFYS4CA0015$0	Butanoic acid
	2 ↔ 2 3 ↔ 1

S- [2- [3- [ [ (2R) -4- [ [ [ (2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] ethanethioate	<Mapping> AtomMap:BMFYS2ESa001$BMFYS4CA0015$0	Butanoic acid
	1 ↔ 3 2 ↔ 4

2 NADPH + Hexanoyl-CoA + Malonyl-CoA = 2 NADP+ + 2 CoA + CO2 + Octanoic acid
(links: NADP+ + Hexanoyl-CoA + Malonyl-CoA + CO2 = NADPH + CoA + Malonyl-CoA + Octanoic acid)

NADP+	<Mapping> AtomMap:BMCCPUAPt033$BMCCPUAPt034$0	NADPH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

NADP+	<Mapping> AtomMap:BMCCPUAPt033$BMCCPUAPt034$0	NADPH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

Hexanoyl-CoA	<Mapping> AtomMap:BMFYS6ESa003$BMCCPUAPf023$0	CoA
	8 ↔ 1 9 ↔ 2 10 ↔ 3 11 ↔ 4 12 ↔ 5 13 ↔ 6 14 ↔ 7 15 ↔ 8 16 ↔ 9 17 ↔ 10 18 ↔ 11 19 ↔ 12 20 ↔ 13 21 ↔ 14 22 ↔ 15 39 ↔ 32 40 ↔ 33 41 ↔ 35 42 ↔ 34 43 ↔ 36 44 ↔ 37 45 ↔ 38 46 ↔ 39 47 ↔ 40 48 ↔ 41 49 ↔ 42 50 ↔ 43 51 ↔ 44 52 ↔ 45

Malonyl-CoA	<Mapping> AtomMap:BMFYS3CAa020$BMCCPUAPf023$0	CoA
	7 ↔ 1 8 ↔ 2 9 ↔ 3 10 ↔ 4 11 ↔ 5 12 ↔ 6 13 ↔ 7 14 ↔ 8 15 ↔ 9 16 ↔ 10 17 ↔ 11 18 ↔ 12 19 ↔ 13 20 ↔ 14 21 ↔ 15 38 ↔ 32 39 ↔ 33 40 ↔ 35 41 ↔ 34 42 ↔ 36 43 ↔ 37 44 ↔ 38 45 ↔ 39 46 ↔ 40 47 ↔ 41 48 ↔ 42 49 ↔ 43 50 ↔ 44 51 ↔ 45

CO2	<Mapping> AtomMap:BMXXSX--0007$BMFYS3CAa020$0	Malonyl-CoA
	1 ↔ 1

Malonyl-CoA	<Mapping> AtomMap:BMFYS3CAa020$BMFYS8CA0002$0	Octanoic acid
	2 ↔ 2 3 ↔ 1

Hexanoyl-CoA	<Mapping> AtomMap:BMFYS6ESa003$BMFYS8CA0002$0	Octanoic acid
	1 ↔ 3 2 ↔ 4 3 ↔ 5 4 ↔ 6 5 ↔ 7 6 ↔ 8

2 NADPH + Butanoyl-CoA + Malonyl-CoA = 2 NADP+ + 2 CoA + CO2 + Hexanoic acid
(links: NADP+ + CoA + Malonyl-CoA + CO2 + Butanoyl-CoA = NADPH + Butanoyl-CoA + CoA + Malonyl-CoA + Hexanoic acid)

NADP+	<Mapping> AtomMap:BMCCPUAPt033$BMCCPUAPt034$0	NADPH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

NADP+	<Mapping> AtomMap:BMCCPUAPt033$BMCCPUAPt034$0	NADPH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

CoA	<Mapping> AtomMap:BMCCPUAPf023$BMFYS4ESa005$0	Butanoyl-CoA
	1 ↔ 6 2 ↔ 7 3 ↔ 8 4 ↔ 9 5 ↔ 10 6 ↔ 11 7 ↔ 12 8 ↔ 13 9 ↔ 14 10 ↔ 15 11 ↔ 16 12 ↔ 17 13 ↔ 18 14 ↔ 19 15 ↔ 20 32 ↔ 37 33 ↔ 38 34 ↔ 39 35 ↔ 40 36 ↔ 41 37 ↔ 42 38 ↔ 43 39 ↔ 44 40 ↔ 45 41 ↔ 46 42 ↔ 47 43 ↔ 48 44 ↔ 49 45 ↔ 50

Malonyl-CoA	<Mapping> AtomMap:BMFYS3CAa020$BMCCPUAPf023$0	CoA
	7 ↔ 1 8 ↔ 2 9 ↔ 3 10 ↔ 4 11 ↔ 5 12 ↔ 6 13 ↔ 7 14 ↔ 8 15 ↔ 9 16 ↔ 10 17 ↔ 11 18 ↔ 12 19 ↔ 13 20 ↔ 14 21 ↔ 15 38 ↔ 32 39 ↔ 33 40 ↔ 35 41 ↔ 34 42 ↔ 36 43 ↔ 37 44 ↔ 38 45 ↔ 39 46 ↔ 40 47 ↔ 41 48 ↔ 42 49 ↔ 43 50 ↔ 44 51 ↔ 45

CO2	<Mapping> AtomMap:BMXXSX--0007$BMFYS3CAa020$0	Malonyl-CoA
	1 ↔ 1

Malonyl-CoA	<Mapping> AtomMap:BMFYS3CAa020$BMFYS6CA0014$0	Hexanoic acid
	2 ↔ 2 3 ↔ 1

Butanoyl-CoA	<Mapping> AtomMap:BMFYS4ESa005$BMFYS6CA0014$0	Hexanoic acid
	1 ↔ 3 2 ↔ 4 3 ↔ 5 4 ↔ 6

@@ Line 3: / Line 3: @@
 |SysName=acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-and enoyl-reducing and thioester-hydrolysing)
 |names=&&fatty-acid synthase&&yeast fatty acid synthase
+}}
+{{Enzyme/Reaction| reaction= 2 NADPH + Acetyl-CoA + Malonyl-CoA = 2 NADP+ + 2 CoA + CO2 + Butanoic acid
+| list=
+&& BMCCPUAPt033$BMCCPUAPt034$0
+&& BMCCPUAPt033$BMCCPUAPt034$0
+&& BMCCPUAPf023$BMFYS2ESa001$0
+&& BMFYS3CAa020$BMCCPUAPf023$0
+&& BMXXSX--0007$BMFYS3CAa020$0
+&& BMFYS3CAa020$BMFYS4CA0015$0
+&& BMFYS2ESa001$BMFYS4CA0015$0
+}}
+{{Enzyme/Reaction| reaction= 2 NADPH + Hexanoyl-CoA + Malonyl-CoA = 2 NADP+ + 2 CoA + CO2 + Octanoic acid
+| list=
+&& BMCCPUAPt033$BMCCPUAPt034$0
+&& BMCCPUAPt033$BMCCPUAPt034$0
+&& BMFYS6ESa003$BMCCPUAPf023$0
+&& BMFYS3CAa020$BMCCPUAPf023$0
+&& BMXXSX--0007$BMFYS3CAa020$0
+&& BMFYS3CAa020$BMFYS8CA0002$0
+&& BMFYS6ESa003$BMFYS8CA0002$0
+}}
+{{Enzyme/Reaction| reaction= 2 NADPH + Butanoyl-CoA + Malonyl-CoA = 2 NADP+ + 2 CoA + CO2 + Hexanoic acid
+| list=
+&& BMCCPUAPt033$BMCCPUAPt034$0
+&& BMCCPUAPt033$BMCCPUAPt034$0
+&& BMCCPUAPf023$BMFYS4ESa005$0
+&& BMFYS3CAa020$BMCCPUAPf023$0
+&& BMXXSX--0007$BMFYS3CAa020$0
+&& BMFYS3CAa020$BMFYS6CA0014$0
+&& BMFYS4ESa005$BMFYS6CA0014$0
 }}

IDs and Links
IUBMB	EC2
ExPaSy	NiceZyme 2.3.1.85