Enzyme:2.1.2.1

Upper Levels: EC2.-.-.- Transferases. : EC2.1.-.- Transferring one-carbon groups. : EC2.1.2.- Hydroxymethyl-, formyl- and related transferases.

IDs and Links
IUBMB	EC2
ExPaSy	NiceZyme 2.1.2.1

5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase
Systematic Name	5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase
Common Name	glycine hydroxymethyltransferase serine aldolase threonine aldolase serine hydroxymethylase serine hydroxymethyltransferase

L-Threonine = Glycine + Acetaldehyde (links: (2R,3S) -2-Amino-3-hydroxybutanoic acid = 2-Amino-acetic acid + Acetaldehyde)
(2R,3S) -2-Amino-3-hydroxybutanoic acid <Mapping> AtomMap:BMAAS4HO0004$BMAAS2AK0001$0 2-Amino-acetic acid 1 ↔ 1 2 ↔ 2 5 ↔ 3 (2R,3S) -2-Amino-3-hydroxybutanoic acid <Mapping> AtomMap:BMAAS4HO0004$BMFYS2AL0001$0 Acetaldehyde 3 ↔ 1 4 ↔ 2

3-Hydroxy-N6,N6,N6-trimethyl-L-lysine = 4-Trimethyl-ammonio-butanal + Glycine (links: [(5S) -5-Amino-4,6-dihydroxy-6-oxohexyl] -trimethylazanium = 4-Trimethyl-ammonio-butanal + 2-Amino-acetic acid)
[(5S) -5-Amino-4,6-dihydroxy-6-oxohexyl] -trimethylazanium <Mapping> AtomMap:BMAXS6ANq001$BMFYB4ALb004$0 4-Trimethyl-ammonio-butanal 3 ↔ 1 4 ↔ 2 5 ↔ 3 6 ↔ 4 8 ↔ 5 9 ↔ 8 10 ↔ 7 11 ↔ 6 [(5S) -5-Amino-4,6-dihydroxy-6-oxohexyl] -trimethylazanium <Mapping> AtomMap:BMAXS6ANq001$BMAAS2AK0001$0 2-Amino-acetic acid 1 ↔ 1 2 ↔ 2 7 ↔ 3

L-Tetrahydro-folic acid + L-Serine = 5,10-Methylene-tetrahydro-folic acid + Glycine + H2O (links: L-Tetrahydro-folic acid + (2S) -2-Amino-3-hydroxypropanoic acid = 5,10-Methylene-tetrahydro-folic acid + 2-Amino-acetic acid)

L-Tetrahydro-folic acid <Mapping> AtomMap:BMCCPTFO0013$BMCCPTFOs005$0 5,10-Methylene-tetrahydro-folic acid 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 14 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 15 15 ↔ 20 16 ↔ 19 17 ↔ 18 18 ↔ 17 19 ↔ 16 20 ↔ 21 21 ↔ 22 22 ↔ 23 23 ↔ 24 24 ↔ 25 25 ↔ 26 26 ↔ 27 (2S) -2-Amino-3-hydroxypropanoic acid <Mapping> AtomMap:BMAAS3HO0002$BMAAS2AK0001$0 2-Amino-acetic acid 1 ↔ 1 2 ↔ 2 4 ↔ 3 (2S) -2-Amino-3-hydroxypropanoic acid <Mapping> AtomMap:BMAAS3HO0002$BMCCPTFOs005$0 5,10-Methylene-tetrahydro-folic acid 3 ↔ 9