Enzyme:1.5.1.12

Revision as of 09:00, 2 February 2009

Upper Levels: EC1.-.-.- Oxidoreductases. : EC1.5.-.- Acting on the CH-NH group of donors. : EC1.5.1.- With NAD(+) or NADP(+) as acceptor.

1-pyrroline-5-carboxylate:NAD+ oxidoreductase
Systematic Name	1-pyrroline-5-carboxylate:NAD+ oxidoreductase
Common Name	1-pyrroline-5-carboxylate dehydrogenase delta1-pyrroline-5-carboxylate dehydrogenase 1-pyrroline dehydrogenase pyrroline-5-carboxylic acid dehydrogenase L-pyrroline-5-carboxylate-NAD+ oxidoreductase

NAD+ + L-4-Hydroxy-glutamate semialdehyde + H2O => NADH + L-erythro-4-Hydroxy-glutamic acid
(links: NAD+ + (2S,4R) -2-Amino-4-hydroxy-5-oxopentanoic = NADH + L-erythro-4-Hydroxy-glutamic acid)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

(2S,4R) -2-Amino-4-hydroxy-5-oxopentanoic	<Mapping> AtomMap:BMAAS5ALq001$BMAAS5CAq004$0	L-erythro-4-Hydroxy-glutamic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6

NAD+ + L-1-Pyrroline-3-hydroxy-5-carboxylic acid => NADH + trans-4-Hydroxy-L-proline
(links: NAD+ + (2S,4R) -4-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid = NADH + (2S,4R) -4-Hydroxypyrrolidine-2-carboxylic acid)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

(2S,4R) -4-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid	<Mapping> AtomMap:BMMCHC--k023$BMACPLHO0010$0	(2S,4R) -4-Hydroxypyrrolidine-2-carboxylic acid
	1 ↔ 1 2 ↔ 5 3 ↔ 4 4 ↔ 3 5 ↔ 2 6 ↔ 6

NAD+ + L-1-Pyrroline-3-hydroxy-5-carboxylic acid + 2 H2O => NADH + 4-Hydroxy-L-glutamic acid
(links: NAD+ + (2S,4R) -4-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid = NADH + 4-Hydroxy-L-glutamic acid)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

(2S,4R) -4-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid	<Mapping> AtomMap:BMMCHC--k023$BMAAS5CAq001$0	4-Hydroxy-L-glutamic acid
	1 ↔ 6 2 ↔ 5 3 ↔ 4 4 ↔ 3 5 ↔ 2 6 ↔ 1

NAD+ + L-Glutamate 5-semialdehyde + H2O => NADH + L-Glutamic acid
(links: NAD+ + L-Glutamate 5-semialdehyde = NADH + (2S) -2-Amino-pentanedioic acid)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

L-Glutamate 5-semialdehyde	<Mapping> AtomMap:BMAAS5AL0002$BMAAS5CA0007$0	(2S) -2-Amino-pentanedioic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6

NAD+ + N2-Succinyl-L-glutamate 5-semialdehyde + H2O => NADH + N2-Succinyl-L-glutamic acid
(links: NAD+ + (2S) -2- [(4-Hydroxy-4-oxobutanoyl) amino] -5-oxopentanoic acid = NADH + N2-Succinyl-L-glutamic acid)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

(2S) -2- [(4-Hydroxy-4-oxobutanoyl) amino] -5-oxopentanoic acid	<Mapping> AtomMap:BMAXS5ALj001$BMAXS5CAj002$0	N2-Succinyl-L-glutamic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10

NAD+ + L-1-Pyrroline-3-hydroxy-5-carboxylic acid + 2 H2O => NADH + L-erythro-4-Hydroxy-glutamic acid
(links: NAD+ + (2S,4R) -4-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid = NADH + L-erythro-4-Hydroxy-glutamic acid)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

(2S,4R) -4-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid	<Mapping> AtomMap:BMMCHC--k023$BMAAS5CAq004$0	L-erythro-4-Hydroxy-glutamic acid
	1 ↔ 6 2 ↔ 5 3 ↔ 4 4 ↔ 3 5 ↔ 2 6 ↔ 1

NAD+ + (S)-1-Pyrroline-5-carboxylic acid + 2 H2O => NADH + L-Glutamic acid
(links: NAD+ + (2S) -3,4-Dihydro-2H-pyrrole-2-carboxylic acid = NADH + (2S) -2-Amino-pentanedioic acid)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

(2S) -3,4-Dihydro-2H-pyrrole-2-carboxylic acid	<Mapping> AtomMap:BMMCHC--k003$BMAAS5CA0007$0	(2S) -2-Amino-pentanedioic acid
	1 ↔ 6 2 ↔ 5 3 ↔ 4 4 ↔ 3 5 ↔ 2 6 ↔ 1

@@ Line 3: / Line 3: @@
 |SysName=1-pyrroline-5-carboxylate:NAD+ oxidoreductase
 |names=&&1-pyrroline-5-carboxylate dehydrogenase&&delta1-pyrroline-5-carboxylate dehydrogenase&&1-pyrroline dehydrogenase&&pyrroline-5-carboxylic acid dehydrogenase&&L-pyrroline-5-carboxylate-NAD+ oxidoreductase
+}}
+{{Enzyme/Reaction| reaction= NAD+ + L-4-Hydroxy-glutamate semialdehyde + H2O => NADH + L-erythro-4-Hydroxy-glutamic acid
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMAAS5ALq001$BMAAS5CAq004$0
+}}
+{{Enzyme/Reaction| reaction= NAD+ + L-1-Pyrroline-3-hydroxy-5-carboxylic acid  => NADH + trans-4-Hydroxy-L-proline
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMMCHC--k023$BMACPLHO0010$0
+}}
+{{Enzyme/Reaction| reaction= NAD+ + L-1-Pyrroline-3-hydroxy-5-carboxylic acid + 2 H2O => NADH + 4-Hydroxy-L-glutamic acid
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMMCHC--k023$BMAAS5CAq001$0
+}}
+{{Enzyme/Reaction| reaction= NAD+ + L-Glutamate 5-semialdehyde + H2O => NADH + L-Glutamic acid
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMAAS5AL0002$BMAAS5CA0007$0
+}}
+{{Enzyme/Reaction| reaction= NAD+ + N2-Succinyl-L-glutamate 5-semialdehyde + H2O => NADH + N2-Succinyl-L-glutamic acid
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMAXS5ALj001$BMAXS5CAj002$0
+}}
+{{Enzyme/Reaction| reaction= NAD+ + L-1-Pyrroline-3-hydroxy-5-carboxylic acid + 2 H2O => NADH + L-erythro-4-Hydroxy-glutamic acid
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMMCHC--k023$BMAAS5CAq004$0
+}}
+{{Enzyme/Reaction| reaction= NAD+ + (S)-1-Pyrroline-5-carboxylic acid + 2 H2O => NADH + L-Glutamic acid
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMMCHC--k003$BMAAS5CA0007$0
 }}

IDs and Links
IUBMB	EC1
ExPaSy	NiceZyme 1.5.1.12

Enzyme:1.5.1.12

Revision as of 09:00, 2 February 2009

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