Enzyme:1.4.1.9

Upper Levels: EC1.-.-.- Oxidoreductases. : EC1.4.-.- Acting on the CH-NH(2) group of donors. : EC1.4.1.- With NAD(+) or NADP(+) as acceptor.

IDs and Links
IUBMB	EC1
ExPaSy	NiceZyme 1.4.1.9

L-leucine:NAD+ oxidoreductase (deaminating)
Systematic Name	L-leucine:NAD+ oxidoreductase (deaminating)
Common Name	leucine dehydrogenase L-leucine:NAD+ oxidoreductase, deaminating LeuDH

NAD+ + L-Leucine + H2O => NADH + 4-Methyl-2-oxo-pentanoic acid + NH3 (links: NAD+ + (2S) -2-Amino-4-methylpentanoic acid = NADH + 4-Methyl-2-oxo-pentanoic acid + NH3)

NAD+ <Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0 NADH 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32 (2S) -2-Amino-4-methylpentanoic acid <Mapping> AtomMap:BMAAB5AK0003$BMFYB4CAr013$0 4-Methyl-2-oxo-pentanoic acid 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 (2S) -2-Amino-4-methylpentanoic acid <Mapping> AtomMap:BMAAB5AK0003$BMIONT--0004$0 NH3 7 ↔ 1

NAD+ + L-Isoleucine + H2O => NADH + (R)-2-Oxo-3-methyl-pentanoic acid + NH3 (links: NAD+ + (2S) -2-Amino-3-methylpentanoic acid = NADH +  (R) -2-Oxo-3-methyl-pentanoic acid + NH3)

NAD+ <Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0 NADH 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32 (2S) -2-Amino-3-methylpentanoic acid <Mapping> AtomMap:BMAAB5AK0002$BMFYB5CAr003$0 (R) -2-Oxo-3-methyl-pentanoic acid 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 7 ↔ 6 (2S) -2-Amino-3-methylpentanoic acid <Mapping> AtomMap:BMAAB5AK0002$BMIONT--0004$0 NH3 6 ↔ 1

NAD+ + L-Norleucine + H2O => NADH + 2-Oxo-hexanoic acid + NH3 (links: NAD+ + (2S) -2-Amino-hexanoic acid = NADH + 2-Oxo-hexanoic acid + NH3)

NAD+ <Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0 NADH 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32 (2S) -2-Amino-hexanoic acid <Mapping> AtomMap:BMAXS6AK0001$BMFYS6CAp008$0 2-Oxo-hexanoic acid 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 (2S) -2-Amino-hexanoic acid <Mapping> AtomMap:BMAXS6AK0001$BMIONT--0004$0 NH3 7 ↔ 1

NAD+ + L-Norvaline + H2O => NADH + 2-Oxo-pentanoic acid + NH3 (links: NAD+ + L-Norvaline = NADH + 2-Oxo-pentanoic acid + NH3)

NAD+ <Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0 NADH 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32 L-Norvaline <Mapping> AtomMap:BMAXS5AK0002$BMFYS5CAp009$0 2-Oxo-pentanoic acid 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 L-Norvaline <Mapping> AtomMap:BMAXS5AK0002$BMIONT--0004$0 NH3 6 ↔ 1

NAD+ + L-Valine + H2O => NADH + 3-Methyl-2-oxo-butanoic acid + NH3 (links: NAD+ + (2S) -2-Amino-3-methylbutanoic acid = NADH + 3-Methyl-2-oxo-butanoic acid + NH3)

NAD+ <Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0 NADH 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32 (2S) -2-Amino-3-methylbutanoic acid <Mapping> AtomMap:BMAAB4AK0001$BMFYB4CAr010$0 3-Methyl-2-oxo-butanoic acid 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 (2S) -2-Amino-3-methylbutanoic acid <Mapping> AtomMap:BMAAB4AK0001$BMIONT--0004$0 NH3 6 ↔ 1