Enzyme:1.2.1.27

Upper Levels: EC1.-.-.- Oxidoreductases. : EC1.2.-.- Acting on the aldehyde or oxo group of donors. : EC1.2.1.- With NAD(+) or NADP(+) as acceptor.

IDs and Links
IUBMB	EC1
ExPaSy	NiceZyme 1.2.1.27

2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)
Systematic Name	2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)
Common Name	methylmalonate-semialdehyde dehydrogenase (acylating)

NAD+ + CoA + (S)-Methyl-malonate semialdehyde => NADH + Propanoyl-CoA + CO2 (links: NAD+ + CoA + CO2 +  (2S) - 2-Methyl-3-oxopropanoic acid = NADH + Propanoyl-CoA +  (2S) - 2-Methyl-3-oxopropanoic acid)

NAD+ <Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0 NADH 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32 CoA <Mapping> AtomMap:BMCCPUAPf023$BMFYS3ESa001$0 Propanoyl-CoA 1 ↔ 5 2 ↔ 6 3 ↔ 7 4 ↔ 8 5 ↔ 9 6 ↔ 10 7 ↔ 11 8 ↔ 12 9 ↔ 13 10 ↔ 14 11 ↔ 15 12 ↔ 16 13 ↔ 17 14 ↔ 18 15 ↔ 19 32 ↔ 36 33 ↔ 37 34 ↔ 38 35 ↔ 39 36 ↔ 40 37 ↔ 41 38 ↔ 42 39 ↔ 43 40 ↔ 44 41 ↔ 45 42 ↔ 46 43 ↔ 47 44 ↔ 48 45 ↔ 49 CO2 <Mapping> AtomMap:BMXXSX--0007$BMFYB3SAr001$0 (2S) - 2-Methyl-3-oxopropanoic acid 1 ↔ 1 (2S) - 2-Methyl-3-oxopropanoic acid <Mapping> AtomMap:BMFYB3SAr001$BMFYS3ESa001$0 Propanoyl-CoA 2 ↔ 2 3 ↔ 1 4 ↔ 3