Doc:Tea/Health

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Tea and Human Health (健康情報)

Cancer 癌

As below, none of the large-scale epidemiological studies showed a significant association of tea intake with a lower risk of cancer[1]. However, many case-control studies and cross-sectional studies (up to several hundreds people) show a decrease of the risk of cancer.

  • Breast cancer 乳がん
Two prospective studies with 35,004 women [2] → no association
  • Gastrointestinal cancer 胃腸がん
Prospective cohort 14873 men and 23667 women [3] → no association
Prospective cohort 11902 men and 14409 women [4] → no association
Prospective cohort 30370 men and 42481 women [5] → no association
Prospective cohort 18746 men and 26184 women [6] → no association
  • Bladder cancer 膀胱がん
Prospective cohort 14873 men and 23667 women [3] → no association
  • Cancer incidence がん
Prospective study 38540 people [3] → no association
References
  1. Borrelli F, Capasso R et al. (2004) "Systematic review: green tea and gastrointestinal cancer risk" Aliment Pharmacol Ther 19:497-510
  2. Suzuki Y, Tsubono Y et al. (2004) "Gren tea and the risk of breast cancer: pooled analysis of two prospective studies in Japan" Br J Cancer 90:1361-1363
  3. 3.0 3.1 3.2 Nagano J, Kono S et al. (2001) "A prospective study of green tea consumption and cancer incidence, Hiroshima and Nagasaki (Japan)" Cancer Causes Control 12:501-508
  4. Tsubono Y, Nishino Y et al. (2001) "Green tea and the risk of gastric cancer in Japan" New Engl J Med 344:632-636
  5. Hoshiyama Y, Kawaguchi T et al. (2002) "A prospective study of stomach cancer death in relation to green tea consumption in Japan" Br J Cancer 87:309-313
  6. Fujino Y, tamakoshi A et al. (2002) "Prospective study of education background and stomach cancer in Japan" Prev Med 35:121-127

Cardiovascular Disease (CVD) 循環器疾患

It is often believed that (oolong) tea possesses hypotensive effects. After Hertog MG et al.[1], flavonoid intakes have been reported to inversely associated with CVDs. In 2008, Hooper et al. performed a comprehensive review of reliable 133 flavonoid trials[2], and concluded that

  • flavanol-rich cocoa reduces blood pressure by 6 (systolic) and 3 (diastolic) mm Hg,
  • soy protein, which is rich in isoflavones, reduces LDL cholesterol by 0.2 mmol/L,
  • black tea acutely (not chronic) raises blood pressure by 6 (systolic) and 3 (diastolic) mm Hg, and
  • chocolate acutely (not chronic) increases flow-mediated dilation (FMD) by 4%.
At least, cocoa and soy (not tea) provide evidence for beneficial effects on CVD. However, it remains unclear whether the effects can be attributed to the specific flavonoid species[3]. A large scale cohort study (34789 men) found no association with flavonoids and CVD [4].


References
  1. Hertog MG, Feskens EJ (1993) "Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study" Lancet 342(8878):1007-1011
  2. Hooper L, Kroon PA, Rimm EB, et al. "Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials" Am J Clin Nutr 88:38–50
  3. Geleijnse JM, Hollman PCH (2008) "Flavonoids and cardiovascular health: which compounds, what mechanisms?" Am J Clin Nutr 88:12-13
  4. Rimm EB, Katan MB (1996) "Relation between intake of flavonoids and risk for coronary heart disease in male health professionals" Ann Intern Med 125(5):384-389 and Huxley RR, Neil HA (2003) "The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies" Eur J Clin Nutr 57:904–908

Obesity 肥満

Recently, resveratrol is found to improve obesity.[1]. Some studies suggest relationship between green tea consumption and reduction in body fat[2][3], but clear evidence on body weight control is missing. Since body weight may change for various reasons, it is hard to conduct an epidemiologic study.

References
  1. Baur JA et al. Sinclair DA (2006) "Resveratrol improves health and survival of mice on a high-calorie diet" Nature 444:337-342
  2. Wu CH, Lu FH et al. (2003) "Relationship among habitual tea consumption, percent body fat, and body fat distribution" Obes Res 11:1088-1095
  3. Tian WX, Li LC et al. (2004) "Weight reduction by Chinese medicinal herbs may be related to inhibition of fatty acid synthase" Life Sci 74:2389-2399
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