Category:PK/References

Revision as of 10:39, 18 October 2012

1. Ahuja M, Chiang YM, Chang SL, Praseuth MB, Entwistle R, Sanchez JF, Lo HC, Yeh HH, Oakley BR, Wang CC: Illuminating the diversity of aromatic polyketide synthases in aspergillus nidulans. J Am Chem Soc, 2012
2. Akamatsu HO, Chilvers MI, Stewart JE, Peever TL: Identification and function of a polyketide synthase gene responsible for 1,8-dihydroxynaphthalene-melanin pigment biosynthesis in ascochyta rabiei. Curr Genet 56(4):349-360, 2010
3. Akey DL, Razelun JR, Tehranisa J, Sherman DH, Gerwick WH, Smith JL: Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway. Structure 18(1):94-105, 2010
4. Atoui A, Dao HP, Mathieu F, Lebrihi A: Amplification and diversity analysis of ketosynthase domains of putative polyketide synthase genes in aspergillus ochraceus and aspergillus carbonarius producers of ochratoxin a. Mol. Nutr. Food Res. 50(6):488-493, 2006
5. Awakawa T, Kaji T, Wakimoto T, Abe I: A heptaketide naphthaldehyde produced by a polyketide synthase from nectria haematococca. Bioorg. Med. Chem. Lett. 22(13):4338-4340, 2012
6. Bacha N, Dao HP, Atoui A, Mathieu F, O'Callaghan J, Puel O, Liboz T, Dobson AD, Lebrihi A: Cloning and characterization of novel methylsalicylic acid synthase gene involved in the biosynthesis of isoasperlactone and asperlactone in aspergillus westerdijkiae. Fungal Genet Biol 46(10):742-749, 2009
7. Bacha N, Mathieu F, Liboz T, Lebrihi A: Polyketide synthase gene aolc35-12 controls the differential expression of ochratoxin a gene aoks1 in aspergillus westerdijkiae. World Mycotoxin Journal 5(2):177-186, 2012
8. Bailey AM, Cox RJ, Harley K, Lazarus CM, Simpson TJ, Skellam E: Characterisation of 3-methylorcinaldehyde synthase (mos) in acremonium strictum: First observation of a reductive release mechanism during polyketide biosynthesis. Chem Commun (Camb) (39):4053-4055, 2007
9. Brown DW, Yu JH, Kelkar HS, Fernandes M, Nesbitt TC, Keller NP, Adams TH, Leonard TJ: Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in aspergillus nidulans. Proc Natl Acad Sci U S A 93(4):1418-1422, 1996
10. Busche A, Gottstein D, Hein C, Ripin N, Pader I, Tufar P, Eisman EB, Gu L, Walsh CT, Sherman DH, Lohr F, Guntert P, Dotsch V: Characterization of molecular interactions between acp and halogenase domains in the curacin a polyketide synthase. ACS Chem Biol 7(2):378-386, 2012
11. Cary JW, Ehrlich KC, Beltz SB, Harris-Coward P, Klich MA: Characterization of the aspergillus ochraceoroseus aflatoxin/sterigmatocystin biosynthetic gene cluster. Mycologia 101(3):352-362, 2009
12. Castoe TA, Stephens T, Noonan BP, Calestani C: A novel group of type I polyketide synthases (PKS) in animals and the complex phylogenomics of PKSs. Gene 392:47-58, 2007
13. Chang Z, Sitachitta N, Rossi JV, Roberts MA, Flatt PM, Jia J, Sherman DH,Gerwick WH: Biosynthetic pathway and gene cluster analysis of curacin a, an antitubulin natural product from the tropical marine cyanobacterium lyngbya majuscula. J Nat Prod 67(8):1356-1367, 2004
14. Chen H, Lee MH, Daub ME, Chung KR: Molecular analysis of the cercosporin biosynthetic gene cluster in cercospora nicotianae. Mol Microbiol 64(3):755-770, 2007
15. Cheng Q, Kinney KA, Whitman CP, Szaniszlo PJ: Characterization of two polyketide synthase genes in exophiala lecanii-corni, a melanized fungus with bioremediation potential. Bioorg Chem 32(2):92-108, 2004
16. Chiang YM, Szewczyk E, Davidson AD, Entwistle R, Keller NP, Wang CC, Oakley BR: Characterization of the aspergillus nidulans monodictyphenone gene cluster. Appl Environ Microbiol 76(7):2067-2074, 2010
17. Chiang YM, Szewczyk E, Davidson AD, Keller N, Oakley BR, Wang CC: A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in aspergillus nidulans. J Am Chem Soc 131(8):2965-2970, 2009
18. Chiang YM, Meyer KM, Praseuth M, Baker SE, Bruno KS, Wang CC: Characterization of a polyketide synthase in aspergillus niger whose product is a precursor for both dihydroxynaphthalene (dhn) melanin and naphtho-gamma-pyrone. Fungal Genet Biol 48(4):430-437, 2011
19. Chung KR, Liao HL: Determination of a transcriptional regulator-like gene involved in biosynthesis of elsinochrome phytotoxin by the citrus scab fungus, elsinoe fawcettii. Microbiology 154(Pt 11):3556-3566, 2008
20. Chooi YH, Cacho R, Tang Y: Identification of the viridicatumtoxin and griseofulvin gene clusters from penicillium aethiopicum. Chem Biol 17(5):483-494, 2010
21. Cramer RA, Jr., Stajich JE, Yamanaka Y, Dietrich FS, Steinbach WJ, Perfect JR: Phylogenomic analysis of non-ribosomal peptide synthetases in the genus aspergillus. Gene 383:24-32, 2006
22. Dao HP, Mathieu F, Lebrihi A: Two primer pairs to detect ota producers by pcr method. Int J Food Microbiol 104(1):61-67, 2005
23. Eley KL, Halo LM, Song Z, Powles H, Cox RJ, Bailey AM, Lazarus CM, Simpson TJ: Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus beauveria bassiana. Chembiochem 8(3):289-297, 2007
24. Engh I, Nowrousian M, Kuck U: Regulation of melanin biosynthesis via the dihydroxynaphthalene pathway is dependent on sexual development in the ascomycete sordaria macrospora. FEMS Microbiol Lett 275(1):62-70, 2007
25. Ehrlich KC, Chang PK, Yu J, Cotty PJ: Aflatoxin biosynthesis cluster gene cypa is required for g aflatoxin formation. Appl Environ Microbiol 70(11):6518-6524, 2004
26. Feng B, Wang X, Hauser M, Kaufmann S, Jentsch S, Haase G, Becker JM, Szaniszlo PJ: Molecular cloning and characterization of wdpks1, a gene involved in dihydroxynaphthalene melanin biosynthesis and virulence in wangiella (exophiala) dermatitidis. Infect Immun 69(3):1781-1794, 2001
27. Feng GH, Leonard TJ: Culture conditions control expression of the genes for aflatoxin and sterigmatocystin biosynthesis in Aspergillus parasiticus and A. nidulans. Appl Environ Microbiol 64(6):2275-2277, 1998
28. Fisch KM, Gillaspy AF, Gipson M, Henrikson JC, Hoover AR, Jackson L, Najar FZ, Wagele H, Cichewicz RH: Chemical induction of silent biosynthetic pathway transcription in aspergillus niger. J Ind Microbiol Biotechnol 36(9):1199-1213, 2009
29. Frandsen RJ, Nielsen NJ, Maolanon N, Sorensen JC, Olsson S, Nielsen J, Giese H: The biosynthetic pathway for aurofusarin in Fusarium graminearum reveals a close link between the naphthoquinones and naphthopyrones, Mol Microbiol, 61(4): 1069-1080, 2006
30. Frandsen RJ, Schutt C, Lund BW, Staerk D, Nielsen J, Olsson S, Giese H: Two novel classes of enzymes are required for the biosynthesis of aurofusarin in Fusarium graminearum, J Biol Chem, 286(12): 10419-10428, 2011
31. Fulton TR, Ibrahim N, Losada MC, Grzegorski D, Tkacz JS: A melanin polyketide synthase (pks) gene from nodulisporium sp. That shows homology to the pks1 gene of colletotrichum lagenarium. Mol Gen Genet 262(4-5):714-720, 1999
32. Gaitatzis N, Silakowski B, Kunze B, Nordsiek G, Blocker H, Hofle G, Muller R: The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase. J Biol Chem 277(15):13082-13090, 2002
33. Ghosh R, Chhabra A, Phatale PA, Samrat SK, Sharma J, Gosain A, Mohanty D, Saran S, Gokhale RS: Dissecting the functional role of polyketide synthases in Dictyostelium discoideum: biosynthesis of the differentiation regulating factor 4-methyl-5-pentylbenzene-1,3-diol. J Biol Chem 283(17):11348-11354, 2008
34. Gressler M, Zaehle C, Scherlach K, Hertweck C, Brock M: Multifactorial induction of an orphan pks-nrps gene cluster in aspergillus terreus. Chem Biol 18(2):198-209, 2011
35. Ishiuchi K, Nakazawa T, Ookuma T, Sugimoto S, Sato M, Tsunematsu Y, Ishikawa N, Noguchi H, Hotta K, Moriya H and Watanabe K: Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics. Chembiochem 13(6):846-854, 2012
36. John U, Beszteri B, Derelle E, Van de Peer Y, Read B, Moreau H, Cembella A: Novel insights into evolution of protistan polyketide synthases through phylogenomic analysis. Protist 159:21-30, 2008
37. Karolewiez A, Geisen R: Cloning a part of the ochratoxin a biosynthetic gene cluster of penicillium nordicum and characterization of the ochratoxin polyketide synthase gene. Syst. Appl. Microbiol. 28(7):588-595, 2005
38. Kim YT, Lee YR, Jin J, Han KH, Kim H, Kim JC, Lee T, Yun SH, Lee YW: Two different polyketide synthase genes are required for synthesis of zearalenone in gibberella zeae. Mol Microbiol 58(4):1102-1113, 2005
39. Li Y, Image, II, Xu W, Image I, Tang Y: Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem 285(30):22764-22773, 2010
40. Liao HL, Chung KR: Genetic dissection defines the roles of elsinochrome phytotoxin for fungal pathogenesis and conidiation of the citrus pathogen elsinoe fawcettii. Mol Plant Microbe Interact 21(4):469-479, 2008
41. Linnemannstons P, Schulte J, del Mar Prado M, Proctor RH, Avalos J, Tudzynski B: The polyketide synthase gene pks4 from gibberella fujikuroi encodes a key enzyme in the biosynthesis of the red pigment bikaverin. Fungal Genet Biol 37(2):134-148, 2002
42. Llorente C, Barcena A, Vera Bahima J, Saparrat MC, Arambarri AM, Rozas MF, Mirifico MV, Balatti PA: Cladosporium cladosporioides lpsc 1088 produces the 1,8-dihydroxynaphthalene-melanin-like compound and carries a putative pks gene. Mycopathologia, 2012
43. Lo HC, Entwistle R, Guo CJ, Ahuja M, Szewczyk E, Hung JH, Chiang YM, Oakley BR, Wang CC: Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in aspergillus nidulans. J Am Chem Soc 134(10):4709-4720, 2012
44. Malz S, Grell MN, Thrane C, Maier FJ, Rosager P, Felk A, Albertsen KS, Salomon S, Bohn L, Schafer W, Giese H: Identification of a gene cluster responsible for the biosynthesis of aurofusarin in the fusarium graminearum species complex. Fungal Genet Biol 42(5):420-433, 2005
45. Mayorga ME, Timberlake WE: The developmentally regulated aspergillus nidulans wa gene encodes a polypeptide homologous to polyketide and fatty acid synthases. Molecular & general genetics : MGG 235(2-3):205-212, 1992
46. Moriwaki A, Kihara J, Kobayashi T, Tokunaga T, Arase S, Honda Y: Insertional mutagenesis and characterization of a polyketide synthase gene (pks1) required for melanin biosynthesis in bipolaris oryzae. FEMS Microbiol Lett 238(1):1-8, 2004
47. Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS, Arroyo J, Berriman M, Abe K, Archer DB, Bermejo C, Bennett J, Bowyer P, Chen D, Collins M, Coulsen R, Davies R, Dyer PS, Farman M, Fedorova N, Feldblyum TV, Fischer R, Fosker N, Fraser A, Garcia JL, Garcia MJ, Goble A, Goldman GH, Gomi K, Griffith-Jones S, Gwilliam R, Haas B, Haas H, Harris D, Horiuchi H, Huang J, Humphray S, Jimenez J, Keller N, Khouri H, Kitamoto K, Kobayashi T, Konzack S, Kulkarni R, Kumagai T, Lafon A, Latge JP, Li W, Lord A, Lu C, Majoros WH, May GS, Miller BL, Mohamoud Y, Molina M, Monod M, Mouyna I, Mulligan S, Murphy L, O'Neil S, Paulsen I, Penalva MA, Pertea M, Price C, Pritchard BL, Quail MA, Rabbinowitsch E, Rawlins N, Rajandream MA, Reichard U, Renauld H, Robson GD, Rodriguez de Cordoba S, Rodriguez-Pena JM, Ronning CM, Rutter S, Salzberg SL, Sanchez M, Sanchez-Ferrero JC, Saunders D, Seeger K, Squares R, Squares S, Takeuchi M, Tekaia F, Turner G, Vazquez de Aldana CR, Weidman J, White O, Woodward J, Yu JH, Fraser C, Galagan JE, Asai K, Machida M, Hall N, Barrell B, Denning DW: Genomic sequence of the pathogenic and allergenic filamentous fungus aspergillus fumigatus. Nature 438(7071):1151-1156, 2005
48. Nishizawa A, Arshad AB, Nishizawa T, Asayama M, Fujii K, Nakano T, Harada K, Shirai M: Cloning and characterization of a new hetero-gene cluster of nonribosomal peptide synthetase and polyketide synthase from the cyanobacterium microcystis aeruginosa k-139. J Gen Appl Microbiol 53(1):17-27, 2007
49. O'Callaghan J, Dobson A: Phylogenetic analysis of polyketide synthase genes from aspergillus ochraceus. Mycotoxin Research 22(2):125-133, 2006
50. Oliynyk M, Samborskyy M, Lester JB, Mironenko T, Scott N, Dickens S, Haydock SF and Leadlay PF: Complete genome sequence of the erythromycin-producing bacterium saccharopolyspora erythraea nrrl23338. Nat Biotechnol 25(4):447-453, 2007
51. Pel HJ, de Winde JH, Archer DB, Dyer PS, Hofmann G, Schaap PJ, Turner G, de Vries RP, Albang R, Albermann K, Andersen MR, Bendtsen JD, Benen JA, van den Berg M, Breestraat S, Caddick MX, Contreras R, Cornell M, Coutinho PM, Danchin EG, Debets AJ, Dekker P, van Dijck PW, van Dijk A, Dijkhuizen L, Driessen AJ, d'Enfert C, Geysens S, Goosen C, Groot GS, de Groot PW, Guillemette T, Henrissat B, Herweijer M, van den Hombergh JP, van den Hondel CA, van der Heijden RT, van der Kaaij RM, Klis FM, Kools HJ, Kubicek CP, van Kuyk PA, Lauber J, Lu X, van der Maarel MJ, Meulenberg R, Menke H, Mortimer MA, Nielsen J, Oliver SG, Olsthoorn M, Pal K, van Peij NN, Ram AF, Rinas U, Roubos JA, Sagt CM, Schmoll M, Sun J, Ussery D, Varga J, Vervecken W, van de Vondervoort PJ, Wedler H, Wosten HA, Zeng AP, van Ooyen AJ, Visser J, Stam H: Genome sequencing and analysis of the versatile cell factory aspergillus niger cbs 513.88. Nat Biotechnol 25(2):221-231, 2007
52. Ramaswamy AV, Sorrels CM, Gerwick WH: Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium lyngbya majuscula. J Nat Prod 70(12):1977-1986, 2007
53. Reeves CD, Hu Z, Reid R, Kealey JT: Genes for the biosynthesis of the fungal polyketides hypothemycin from hypomyces subiculosus and radicicol from pochonia chlamydosporia. Appl Environ Microbiol 74(16):5121-5129, 2008
54. Regueira TB, Kildegaard KR, Hansen BG, Mortensen UH, Hertweck C, Nielsen J: Molecular basis for mycophenolic acid biosynthesis in penicillium brevicompactum. Appl Environ Microbiol 77(9):3035-3043, 2011
55. Sanchez JF, Somoza AD, Keller NP, Wang CC: Advances in aspergillus secondary metabolite research in the post-genomic era. Nat Prod Rep 29(3):351-371, 2012
56. Sauer M, Lu P, Sangari R, Kennedy S, Polishook J, Bills G, An Z: Estimating polyketide metabolic potential among nonsporulating fungal endophytes of vaccinium macrocarpon. Mycological Research 106(4):460-470, 2002
57. Schmitt I, Kautz S, Lumbsch HT: 6-MSAS-like polyketide synthase genes occur in lichenized ascomycetes. Mycol Res 112:289-296, 2008
58. Schmitt I, Lumbsch HT: Ancient horizontal gene transfer from bacteria enhances biosynthetic capabilities of fungi. PLoS One 4:e4437, 2009
59. Schwelm A, Bradshaw RE: Genetics of dothistromin biosynthesis of dothistroma septosporum: An update. Toxins 2(11):2680-2698, 2010
60. Shalev-Alon G, Sukenik A, Livnah O, Schwarz R, Kaplan A: A novel gene encoding amidinotransferase in the cylindrospermopsin producing cyanobacterium aphanizomenon ovalisporum. FEMS Microbiol Lett 209(1):87-91, 2002
61. Shimizu T, Kinoshita H, Ishihara S, Sakai K, Nagai S, Nihira T: Polyketide synthase gene responsible for citrinin biosynthesis in monascus purpureus. Appl Environ Microbiol 71(7):3453-3457, 2005
62. Sims JW, Fillmore JP, Warner DD, Schmidt EW: Equisetin biosynthesis in fusarium heterosporum. Chem Commun (Camb) (2):186-188, 2005
63. Slot JC, Rokas A: Horizontal transfer of a large and highly toxic secondary metabolic gene cluster between fungi. Curr Biol 21(2):134-139, 2011
64. Sun H, Ho CL, Ding F, Soehano I, Liu XW and Liang ZX: Synthesis of (r)-mellein by a partially reducing iterative polyketide synthase. J Am Chem Soc 134(29):11924-11927, 2012
65. Sun W, Peng C, Zhao Y, Li Z: Functional Gene-Guided Discovery of Type II Polyketides from Culturable Actinomycetes Associated with Soft Coral Scleronephthya sp, PLoS One, 7(8): e42847, 2012
66. Takano Y, Kubo Y, Shimizu K, Mise K, Okuno T, Furusawa I: Structural analysis of pks1, a polyketide synthase gene involved in melanin biosynthesis in colletotrichum lagenarium. Mol Gen Genet 249(2):162-167, 1995
67. Tanguay P, Tangen K, Breuil C: Identifying pigmentation-related genes in ophiostoma piceae using agrobacterium-mediated integration. Phytopathology 97(9):1040-1048, 2007
68. Thywissen A, Heinekamp T, Dahse HM, Schmaler-Ripcke J, Nietzsche S, Zipfel PF, Brakhage AA: Conidial dihydroxynaphthalene melanin of the human pathogenic fungus aspergillus fumigatus interferes with the host endocytosis pathway. Frontiers in microbiology 296, 2011
69. Tokuoka M, Seshime Y, Fujii I, Kitamoto K, Takahashi T, Koyama Y: Identification of a novel polyketide synthase-nonribosomal peptide synthetase (pks-nrps) gene required for the biosynthesis of cyclopiazonic acid in aspergillus oryzae. Fungal Genet Biol 45(12):1608-1615, 2008
70. Valarmathi R, Hariharan GN, Venkataraman G, Parida A: Characterization of a non-reducing polyketide synthase gene from lichen dirinaria applanata. Phytochemistry 70(6):721-729, 2009
71. Varga J, Rigo K, Kocsube S, Farkas B, Pal K: Diversity of polyketide synthase gene sequences in Aspergillus species. Res Microbiol 154:593-600, 2003
72. Wang S, Xu Y, Maine EA, Wijeratne EM, Espinosa-Artiles P, Gunatilaka AA, Molnar I: Functional characterization of the biosynthesis of radicicol, an hsp90 inhibitor resorcylic acid lactone from chaetomium chiversii. Chem Biol 15(12):1328-1338, 2008
73. Wang Y, Kim JA, Cheong YH, Joshi Y, Koh YJ, Hur JS: Isolation and characterization of a reducing polyketide synthase gene from the lichen-forming fungus usnea longissima. J Microbiol 49(3):473-480, 2011
74. Watanabe A, Fujii I, Sankawa U, Mayorga ME, Timberlake WE, Ebizuka Y: Re-identification of aspergillus nidulans wa gene to code for a polyketide synthase of naphthopyrone. Tetrahedron Letters 40(1):91-94, 1999
75. Watanabe A, Ono Y, Fujii I, Sankawa U, Mayorga ME, Timberlake WE, Ebizuka Y: Product identification of polyketide synthase coded by aspergillus nidulans wa gene. Tetrahedron Letters 39(42):7733-7736, 1998
76. Wortman JR, Gilsenan JM, Joardar V, Deegan J, Clutterbuck J, Andersen MR, Archer D, Bencina M, Braus G, Coutinho P, von Dohren H, Doonan J, Driessen AJ, Durek P, Espeso E, Fekete E, Flipphi M, Estrada CG, Geysens S, Goldman G, de Groot PW, Hansen K, Harris SD, Heinekamp T, Helmstaedt K, Henrissat B, Hofmann G, Homan T, Horio T, Horiuchi H, James S, Jones M, Karaffa L, Karanyi Z, Kato M, Keller N, Kelly DE, Kiel JA, Kim JM, van der Klei IJ, Klis FM, Kovalchuk A, Krasevec N, Kubicek CP, Liu B, Maccabe A, Meyer V, Mirabito P, Miskei M, Mos M, Mullins J, Nelson DR, Nielsen J, Oakley BR, Osmani SA, Pakula T, Paszewski A, Paulsen I, Pilsyk S, Pocsi I, Punt PJ, Ram AF, Ren Q, Robellet X, Robson G, Seiboth B, van Solingen P, Specht T, Sun J, Taheri-Talesh N, Takeshita N, Ussery D, vanKuyk PA, Visser H, van de Vondervoort PJ, de Vries RP, Walton J, Xiang X, Xiong Y, Zeng AP, Brandt BW, Cornell MJ, van den Hondel CA, Visser J, Oliver SG, Turner G: The 2008 update of the aspergillus nidulans genome annotation: A community effort. Fungal Genet Biol 46 Suppl 1S2-13, 2009
77. Yang SL, Chung KR: Transcriptional regulation of elsinochrome phytotoxin biosynthesis by an efste12 activator in the citrus scab pathogen elsinoe fawcettii. Fungal Biol 114(1):64-73, 2010
78. Yu J, Bhatnagar D, Cleveland TE: Completed sequence of aflatoxin pathway gene cluster in Aspergillus parasiticus, FEBS Lett, 564(1-2): 126-130, 2004
79. Yu J, Chang PK, Ehrlich KC, Cary JW, Bhatnagar D, Cleveland TE, Payne GA, Linz JE, Woloshuk CP, Bennett JW: Clustered pathway genes in aflatoxin biosynthesis. Appl Environ Microbiol 70(3):1253-1262, 2004
80. Yu JH, Leonard TJ: Sterigmatocystin biosynthesis in aspergillus nidulans requires a novel type i polyketide synthase. J. Bacteriol. 177(16):4792-4800, 1995
81. Zhang A, Lu P, Dahl-Roshak AM, Paress PS, Kennedy S, Tkacz JS and An Z: Efficient disruption of a polyketide synthase gene ( pks1) required for melanin synthesis through agrobacterium-mediated transformation of glarea lozoyensis. Mol Genet Genomics 268(5):645-655, 2003
82. Zhang X, Parry RJ: Cloning and characterization of the pyrrolomycin biosynthetic gene clusters from actinosporangium vitaminophilum atcc 31673 and streptomyces sp. Strain uc 11065. Antimicrob Agents Chemother 51(3):946-957, 2007