PKS:Afu2g17600

Polyketide Top

Species List

UniRef90 Class

UniRef50 Class

Gene Class

Domains (by CDD)

Domains (by MAPSI)

Aspergillus fumigatus Af293 (GenBank XP_756095) all species
Class	NRPKS (length: 2146) all classes   Class in KS domain phylogeny	Reliability	verified
Product	YWA1(conidial pigment)	GeneName	pksP(alb1)
UniProt,UniRef90	Q4WZA8 , Q4WZA8	UniRef50	Q03149
Domain by MAPSI	KS-AT-ACP-ACP-CYC (notation help / all patterns)
Domain by CDD	KS-AT-PP-PP-TE (notation help / all patterns)
Domain by ITER-DB	KS-AT-ACP-ACP-CYC (notation help / all patterns)
Estimated Domain	SAT-KS-AT-PT-ACP-ACP-TE/CLC
Description	Conidial pigment polyketide synthase PksP/Alb1 [Aspergillus fumigatus Af293].Polyketide synthase involved in biosynthesis of the conidial pigment; controlled in part by the cAMP/protein kinase A (PKA) signal transduction pathway; mutants fail to inhibit phagolysosome acidification
Information
References	Ahuja M, Chiang YM, Chang SL, Praseuth MB, Entwistle R, Sanchez JF, Lo HC, Yeh HH, Oakley BR, Wang CC: Illuminating the diversity of aromatic polyketide synthases in aspergillus nidulans. J Am Chem Soc, 2012 Langfelder K, Jahn B, Gehringer H, Schmidt A, Wanner G and Brakhage AA: Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence. Med Microbiol Immunol 187(2): 79-89. 1998 Li Y, Image, II, Xu W, Image I, Tang Y: Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem 285(30):22764-22773, 2010 Thywissen A, Heinekamp T, Dahse HM, Schmaler-Ripcke J, Nietzsche S, Zipfel PF, Brakhage AA: Conidial dihydroxynaphthalene melanin of the human pathogenic fungus aspergillus fumigatus interferes with the host endocytosis pathway. Frontiers in microbiology 296, 2011
Link	AspGD

This work is performed by ShuHsi Lin (TW), Toshitaka Kumagai and Masanori Arita (JP)