Enzyme:1.2.4.1

Basic Metabolism Top (代謝トップ)

Molecule Index (化合物索引)

EC classes ( EC分類)

Input New Data (新規入力)

Upper Levels: EC1.-.-.- Oxidoreductases. : EC1.2.-.- Acting on the aldehyde or oxo group of donors. : EC1.2.4.- With a disulfide as acceptor.

IDs and Links
IUBMB	EC1
ExPaSy	NiceZyme 1.2.4.1

pyruvate:[dihydrolipoyllysine-residueacetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating,acceptor-acetylating)
Systematic Name	pyruvate:[dihydrolipoyllysine-residueacetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating,acceptor-acetylating)
Common Name	pyruvate dehydrogenase (acetyl-transferring) MtPDC (mitochondrial pyruvate dehydogenase complex) pyruvate decarboxylase pyruvate dehydrogenase (lipoamide) pyruvate dehydrogenase complex

TPP + Pyruvic acid => 2-(Hydroxyethyl)-thiamine diphosphate + CO2 (links: TPP + 2-Oxo-propanoic acid = 2- (Hydroxyethyl) -thiamine diphosphate + CO2)

TPP <Mapping> AtomMap:BMMCTZ--e012$BMMCTZ--e005$0 2- (Hydroxyethyl) -thiamine diphosphate 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17 2-Oxo-propanoic acid <Mapping> AtomMap:BMXXSX--0007$BMFYS3CAp025$0 CO2 1 ↔ 1 2-Oxo-propanoic acid <Mapping> AtomMap:BMFYS3CAp025$BMMCTZ--e005$0 2- (Hydroxyethyl) -thiamine diphosphate 2 ↔ 18 3 ↔ 19

2-(Hydroxyethyl)-thiamine diphosphate + Lipoamide => TPP + 6-S-Acetyl-dihydro-lipoamide (links: 2- (Hydroxyethyl) -thiamine diphosphate + Lipoamide = TPP + S- (8-Amino-8-oxo-1-sulfanyloctan-3-yl) ethanethioic acid)

2- (Hydroxyethyl) -thiamine diphosphate <Mapping> AtomMap:BMMCTZ--e012$BMMCTZ--e005$0 TPP 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17 Lipoamide <Mapping> AtomMap:BMMCHC--l024$BMFYB8AMf001$0 S- (8-Amino-8-oxo-1-sulfanyloctan-3-yl) ethanethioic acid 1 ↔ 11 2 ↔ 6 3 ↔ 7 4 ↔ 8 5 ↔ 9 6 ↔ 5 7 ↔ 4 8 ↔ 3 9 ↔ 2 10 ↔ 1 11 ↔ 10 2- (Hydroxyethyl) -thiamine diphosphate <Mapping> AtomMap:BMMCTZ--e005$BMFYB8AMf001$0 S- (8-Amino-8-oxo-1-sulfanyloctan-3-yl) ethanethioic acid 18 ↔ 12 19 ↔ 13