Enzyme:2.1.1.6

Upper Levels: EC2.-.-.- Transferases. : EC2.1.-.- Transferring one-carbon groups. : EC2.1.1.- Methyltransferases.

IDs and Links
IUBMB	EC2
ExPaSy	NiceZyme 2.1.1.6

S-adenosyl-L-methionine:catechol O-methyltransferase
Systematic Name	S-adenosyl-L-methionine:catechol O-methyltransferase
Common Name	catechol O-methyltransferase COMT I COMT II S-COMT (soluble form of catechol-O-methyltransferase) MB-COMT (membrane-bound form of catechol-O-methyltransferase)

S-Adenosyl-L-methionine + L-Adrenaline = S-Adenosyl-L-homocysteine + L-Metanephrine (links: S-Adenosyl-L-methionine + 4- [1R-1-Hydroxy-2-(methylamino)ethyl] -1,2-benzenediol = S-Adenosyl-L-homocysteine + 4- [1-Hydroxy-2- (methylamino) ethyl] -2-methoxyphenol)

S-Adenosyl-L-methionine <Mapping> AtomMap:BMCCPUADf014$BMCCPUADf012$0 S-Adenosyl-L-homocysteine 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 8 ↔ 7 9 ↔ 8 10 ↔ 9 11 ↔ 10 12 ↔ 11 13 ↔ 12 14 ↔ 13 15 ↔ 14 16 ↔ 15 17 ↔ 16 18 ↔ 17 19 ↔ 18 20 ↔ 19 21 ↔ 20 22 ↔ 21 4- [1R-1-Hydroxy-2-(methylamino)ethyl] -1,2-benzenediol <Mapping> AtomMap:BMMCBZ3Sm054$BMMCBZ3Sm055$0 4- [1-Hydroxy-2- (methylamino) ethyl] -2-methoxyphenol 1 ↔ 4 2 ↔ 3 3 ↔ 2 4 ↔ 1 5 ↔ 6 6 ↔ 5 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 S-Adenosyl-L-methionine <Mapping> AtomMap:BMCCPUADf014$BMMCBZ3Sm055$0 4- [1-Hydroxy-2- (methylamino) ethyl] -2-methoxyphenol 7 ↔ 12

S-Adenosyl-L-methionine + L-Noradrenaline = S-Adenosyl-L-homocysteine + L-Normetanephrine (links: S-Adenosyl-L-methionine + L-Noradrenaline = S-Adenosyl-L-homocysteine + 4- (2-Amino-1-hydroxyethyl) -2-methoxyphenol)

S-Adenosyl-L-methionine <Mapping> AtomMap:BMCCPUADf014$BMCCPUADf012$0 S-Adenosyl-L-homocysteine 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 8 ↔ 7 9 ↔ 8 10 ↔ 9 11 ↔ 10 12 ↔ 11 13 ↔ 12 14 ↔ 13 15 ↔ 14 16 ↔ 15 17 ↔ 16 18 ↔ 17 19 ↔ 18 20 ↔ 19 21 ↔ 20 22 ↔ 21 L-Noradrenaline <Mapping> AtomMap:BMMCBZ3Sm056$BMMCBZ3Sm057$0 4- (2-Amino-1-hydroxyethyl) -2-methoxyphenol 1 ↔ 4 2 ↔ 3 3 ↔ 2 4 ↔ 1 5 ↔ 6 6 ↔ 5 7 ↔ 7 8 ↔ 8 9 ↔ 9 S-Adenosyl-L-methionine <Mapping> AtomMap:BMCCPUADf014$BMMCBZ3Sm057$0 4- (2-Amino-1-hydroxyethyl) -2-methoxyphenol 7 ↔ 11

S-Adenosyl-L-methionine + 3,4-Dihydroxy-phenyl-acetic acid = S-Adenosyl-L-homocysteine + Homovanillic acid (links: S-Adenosyl-L-methionine + 3,4-Dihydroxy-phenyl-acetic acid = S-Adenosyl-L-homocysteine + 2- (4-Hydroxy-3-methoxyphenyl) acetic acid)

S-Adenosyl-L-methionine <Mapping> AtomMap:BMCCPUADf014$BMCCPUADf012$0 S-Adenosyl-L-homocysteine 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 8 ↔ 7 9 ↔ 8 10 ↔ 9 11 ↔ 10 12 ↔ 11 13 ↔ 12 14 ↔ 13 15 ↔ 14 16 ↔ 15 17 ↔ 16 18 ↔ 17 19 ↔ 18 20 ↔ 19 21 ↔ 20 22 ↔ 21 3,4-Dihydroxy-phenyl-acetic acid <Mapping> AtomMap:BMMCBZ3Sk020$BMMCBZ3Sk053$0 2- (4-Hydroxy-3-methoxyphenyl) acetic acid 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 S-Adenosyl-L-methionine <Mapping> AtomMap:BMCCPUADf014$BMMCBZ3Sk053$0 2- (4-Hydroxy-3-methoxyphenyl) acetic acid 7 ↔ 12