PKS:AN1034

Polyketide Top

Species List

UniRef90 Class

UniRef50 Class

Gene Class

Domains (by CDD)

Domains (by MAPSI)

Aspergillus nidulans FGSC A4 (GenBank XP_658638) all species
Class	NRPKS (length: 2793) all classes   Class in KS domain phylogeny	Reliability	verified
Product	asperfuranone	GeneName	pks13(afoE)
UniProt,UniRef90	C8VTX9 , C8VTX9	UniRef50	C8VTX9
Domain by MAPSI	KS-AT-ACP (notation help / all patterns)
Domain by CDD	KS-AT-PP-ME-TE (notation help / all patterns)
Domain by ITER-DB	KS-AT-ACP (notation help / all patterns)
Estimated Domain	SAT-KS-AT-PT-ACP-ME-R
Description	hypothetical protein AN1034.2 [Aspergillus nidulans FGSC A4]
Information	Putative polyketide synthase; required for asperfuranone biosynthesis; transcriptionally induced by scrP overexpression.
References	Ahuja M, Chiang YM, Chang SL, Praseuth MB, Entwistle R, Sanchez JF, Lo HC, Yeh HH, Oakley BR, Wang CC: Illuminating the diversity of aromatic polyketide synthases in aspergillus nidulans. J Am Chem Soc, 2012 Andersen M R, Nielsen J B, Klitgaard A, Petersen L M, Zachariasen M, Hansen T J, Blicher L H, Gotfredsen C H, Larsen T O, Nielsen K F, Mortensen U H: Accurate prediction of secondary metabolite gene clusters in filamentous fungi. Proc Natl Acad Sci U S A 110(1): E99-107. 2013 Chiang YM, Szewczyk E, Davidson AD, Keller N, Oakley BR, Wang CC: A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in aspergillus nidulans. J Am Chem Soc 131(8):2965-2970, 2009 Fisch KM, Gillaspy AF, Gipson M, Henrikson JC, Hoover AR, Jackson L, Najar FZ, Wagele H, Cichewicz RH: Chemical induction of silent biosynthetic pathway transcription in aspergillus niger. J Ind Microbiol Biotechnol 36(9):1199-1213, 2009
Link	AspGD

This work is performed by ShuHsi Lin (TW), Toshitaka Kumagai and Masanori Arita (JP)