Enzyme:6.2.1.12

Upper Levels: EC6.-.-.- Ligases. : EC6.2.-.- Forming carbon-sulfur bonds. : EC6.2.1.- Acid--thiol ligases.

IDs and Links
IUBMB	EC6
ExPaSy	NiceZyme 6.2.1.12

4-coumarate:CoA ligase (AMP-forming)
Systematic Name	4-coumarate:CoA ligase (AMP-forming)
Common Name	4-coumarate-CoA ligase 4-coumaroyl-CoA synthetase p-coumaroyl CoA ligase p-coumaryl coenzyme A synthetase feruloyl CoA ligase

CoA + ATP + trans-4-Hydroxy-cinnamic acid => 4-Coumaroyl-CoA + AMP + Pyrophosphate (links: CoA + ATP + trans-3- (4-Hydroxyphenyl) prop-2-enoic acid = 4-Coumaroyl-CoA + AMP)

CoA <Mapping> AtomMap:BMCCPUAPf023$BMMCBZ2Pa016$0 4-Coumaroyl-CoA 1 ↔ 12 2 ↔ 13 3 ↔ 14 4 ↔ 15 5 ↔ 16 6 ↔ 17 7 ↔ 18 8 ↔ 19 9 ↔ 20 10 ↔ 21 11 ↔ 22 12 ↔ 23 13 ↔ 24 14 ↔ 25 15 ↔ 26 32 ↔ 43 33 ↔ 44 34 ↔ 46 35 ↔ 45 36 ↔ 47 37 ↔ 48 38 ↔ 49 39 ↔ 50 40 ↔ 51 41 ↔ 52 42 ↔ 53 43 ↔ 54 44 ↔ 55 45 ↔ 56 ATP <Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0021$0 AMP 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 trans-3- (4-Hydroxyphenyl) prop-2-enoic acid <Mapping> AtomMap:BMMCBZ2Pk059$BMMCBZ2Pa016$0 4-Coumaroyl-CoA 1 ↔ 1 2 ↔ 6 3 ↔ 5 4 ↔ 4 5 ↔ 3 6 ↔ 2 7 ↔ 7 8 ↔ 8 9 ↔ 9

CoA + ATP + Sinapic acid => Sinapoyl-CoA + AMP + Pyrophosphate (links: CoA + ATP + trans-3- (4-Hydroxy-3,5-dimethoxyphenyl) prop-2-enoic acid = Sinapoyl-CoA + AMP)

CoA <Mapping> AtomMap:BMCCPUAPf023$BMMCBZ4Sa013$0 Sinapoyl-CoA 1 ↔ 16 2 ↔ 17 3 ↔ 18 4 ↔ 19 5 ↔ 20 6 ↔ 21 7 ↔ 22 8 ↔ 23 9 ↔ 24 10 ↔ 25 11 ↔ 26 12 ↔ 27 13 ↔ 28 14 ↔ 29 15 ↔ 30 32 ↔ 47 33 ↔ 48 34 ↔ 50 35 ↔ 49 36 ↔ 51 37 ↔ 52 38 ↔ 53 39 ↔ 54 40 ↔ 55 41 ↔ 56 42 ↔ 57 43 ↔ 58 44 ↔ 59 45 ↔ 60 ATP <Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0021$0 AMP 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 trans-3- (4-Hydroxy-3,5-dimethoxyphenyl) prop-2-enoic acid <Mapping> AtomMap:BMMCBZ4Sk009$BMMCBZ4Sa013$0 Sinapoyl-CoA 1 ↔ 1 2 ↔ 6 3 ↔ 5 4 ↔ 4 5 ↔ 3 6 ↔ 2 7 ↔ 7 8 ↔ 8 9 ↔ 9 13 ↔ 15 16 ↔ 12

CoA + ATP + Caffeic acid => Caffeoyl-CoA + AMP + Pyrophosphate (links: CoA + ATP + trans-3- (3,4-Dihydroxyphenyl) prop-2-enoic acid = Caffeoyl-CoA + AMP)

CoA <Mapping> AtomMap:BMCCPUAPf023$BMMCBZ3Sa045$0 Caffeoyl-CoA 1 ↔ 13 2 ↔ 14 3 ↔ 15 4 ↔ 16 5 ↔ 17 6 ↔ 18 7 ↔ 19 8 ↔ 20 9 ↔ 21 10 ↔ 22 11 ↔ 23 12 ↔ 24 13 ↔ 25 14 ↔ 26 15 ↔ 27 32 ↔ 44 33 ↔ 45 34 ↔ 47 35 ↔ 46 36 ↔ 48 37 ↔ 49 38 ↔ 50 39 ↔ 51 40 ↔ 52 41 ↔ 53 42 ↔ 54 43 ↔ 55 44 ↔ 56 45 ↔ 57 ATP <Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0021$0 AMP 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 trans-3- (3,4-Dihydroxyphenyl) prop-2-enoic acid <Mapping> AtomMap:BMMCBZ3Sk044$BMMCBZ3Sa045$0 Caffeoyl-CoA 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9