Enzyme:2.5.1.48

Upper Levels: EC2.-.-.- Transferases. : EC2.5.-.- Transferring alkyl or aryl groups, other than methyl groups. : EC2.5.1.- Transferring alkyl or aryl groups, other than methyl groups.

IDs and Links
IUBMB	EC2
ExPaSy	NiceZyme 2.5.1.48

O4-succinyl-L-homoserine:L-cysteineS-(3-amino-3-carboxypropyl)transferase
Systematic Name	O4-succinyl-L-homoserine:L-cysteineS-(3-amino-3-carboxypropyl)transferase
Common Name	cystathionine gamma-synthase O-succinyl-L-homoserine succinate-lyase (adding cysteine) O-succinylhomoserine (thiol)-lyase homoserine O-transsuccinylase O-succinylhomoserine synthase

O-Acetyl-L-serine + Thiosulfate = Acetic acid + S-Sulfo-L-cysteine (links: O-Acetyl-L-serine + Sulfurothioic O-acid = Acetic acid + S-Sulfo-L-cysteine)
O-Acetyl-L-serine <Mapping> AtomMap:BMAXS3HOi002$BMFYS2CA0001$0 Acetic acid 5 ↔ 1 6 ↔ 2 Sulfurothioic O-acid <Mapping> AtomMap:BMIOSF--0006$BMAAS3SF0008$0 S-Sulfo-L-cysteine 2 ↔ 6 4 ↔ 5 O-Acetyl-L-serine <Mapping> AtomMap:BMAXS3HOi002$BMAAS3SF0008$0 S-Sulfo-L-cysteine 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4

2-Oxo-butanoic acid + Succinic acid + NH3 = O-Succinyl-L-homoserine + H2O (links: 2-Oxo-butanoic acid + Butanedioic acid + NH3 = (2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid)

2-Oxo-butanoic acid <Mapping> AtomMap:BMFYS4CAp006$BMAXS4ESj002$0 (2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 Butanedioic acid <Mapping> AtomMap:BMFYS4DA0015$BMAXS4ESj002$1 (2nd) (2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid 1 ↔ 9 2 ↔ 8 3 ↔ 7 4 ↔ 6 NH3 <Mapping> AtomMap:BMIONT--0004$BMAXS4ESj002$0 (2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid 1 ↔ 5

O-Succinyl-L-homoserine + L-Cysteine = Succinic acid + L-Cystathionine (links: (2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid + L-Cysteine = Butanedioic acid + L-Cystathionine)

(2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid <Mapping> AtomMap:BMAXS4ESj002$BMFYS4DA0015$0 Butanedioic acid 6 ↔ 4 7 ↔ 3 8 ↔ 2 9 ↔ 1 L-Cysteine <Mapping> AtomMap:BMAAS3SF0003$BMFYB4CAf021$0 L-Cystathionine 1 ↔ 7 2 ↔ 8 3 ↔ 9 4 ↔ 10 5 ↔ 6 (2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid <Mapping> AtomMap:BMAXS4ESj002$BMFYB4CAf021$0 L-Cystathionine 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5

O-Succinyl-L-homoserine + Seleno-L-cysteine = Succinic acid + Seleno-L-cystathionine (links: (2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid + Seleno-L-cysteine = Butanedioic acid + Seleno-L-cystathionine)

(2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid <Mapping> AtomMap:BMAXS4ESj002$BMFYS4DA0015$0 Butanedioic acid 6 ↔ 4 7 ↔ 3 8 ↔ 2 9 ↔ 1 Seleno-L-cysteine <Mapping> AtomMap:BMAAS3MT0001$BMAXDP--c016$0 Seleno-L-cystathionine 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 (2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid <Mapping> AtomMap:BMAXS4ESj002$BMAXDP--c016$0 Seleno-L-cystathionine 1 ↔ 5 2 ↔ 6 3 ↔ 7 4 ↔ 8 5 ↔ 9

O-Acetyl-L-homoserine + L-Cysteine = Acetic acid + L-Cystathionine (links: O-Acetyl-L-homoserine + L-Cysteine = Acetic acid + L-Cystathionine)
O-Acetyl-L-homoserine <Mapping> AtomMap:BMAXS4ESi001$BMFYS2CA0001$0 Acetic acid 6 ↔ 1 7 ↔ 2 L-Cysteine <Mapping> AtomMap:BMAAS3SF0003$BMFYB4CAf021$0 L-Cystathionine 1 ↔ 7 2 ↔ 8 3 ↔ 9 4 ↔ 10 5 ↔ 6 O-Acetyl-L-homoserine <Mapping> AtomMap:BMAXS4ESi001$BMFYB4CAf021$0 L-Cystathionine 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5