Enzyme:1.5.1.2

Upper Levels: EC1.-.-.- Oxidoreductases. : EC1.5.-.- Acting on the CH-NH group of donors. : EC1.5.1.- With NAD(+) or NADP(+) as acceptor.

IDs and Links
IUBMB	EC1
ExPaSy	NiceZyme 1.5.1.2

L-proline:NAD(P)+ 5-oxidoreductase
Systematic Name	L-proline:NAD(P)+ 5-oxidoreductase
Common Name	pyrroline-5-carboxylate reductase proline oxidase 1-pyrroline-5-carboxylate reductase NADPH-L-delta1-pyrroline carboxylic acid reductase L-proline-NAD(P)+ 5-oxidoreductase

NADPH + (S)-1-Pyrroline-5-carboxylic acid = NADP+ + L-Proline (links: NADP+ + (2S) -3,4-Dihydro-2H-pyrrole-2-carboxylic acid = NADPH + (2S) -Pyrrolidine-2-carboxylic acid)

NADP+ <Mapping> AtomMap:BMCCPUAPt033$BMCCPUAPt034$0 NADPH 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32 (2S) -3,4-Dihydro-2H-pyrrole-2-carboxylic acid <Mapping> AtomMap:BMMCHC--k003$BMACPL--0008$0 (2S) -Pyrrolidine-2-carboxylic acid 1 ↔ 1 2 ↔ 5 3 ↔ 4 4 ↔ 3 5 ↔ 2 6 ↔ 6

NADPH + L-1-Pyrroline-3-hydroxy-5-carboxylic acid = NADP+ + trans-4-Hydroxy-L-proline (links: NADP+ + (2S,4R) -4-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid = NADPH + (2S,4R) -4-Hydroxypyrrolidine-2-carboxylic acid)

NADP+ <Mapping> AtomMap:BMCCPUAPt033$BMCCPUAPt034$0 NADPH 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32 (2S,4R) -4-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid <Mapping> AtomMap:BMMCHC--k023$BMACPLHO0010$0 (2S,4R) -4-Hydroxypyrrolidine-2-carboxylic acid 1 ↔ 1 2 ↔ 5 3 ↔ 4 4 ↔ 3 5 ↔ 2 6 ↔ 6

NADH + (S)-1-Pyrroline-5-carboxylic acid = NAD+ + L-Proline (links: NAD+ + (2S) -3,4-Dihydro-2H-pyrrole-2-carboxylic acid = NADH + (2S) -Pyrrolidine-2-carboxylic acid)

NAD+ <Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0 NADH 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32 (2S) -3,4-Dihydro-2H-pyrrole-2-carboxylic acid <Mapping> AtomMap:BMMCHC--k003$BMACPL--0008$0 (2S) -Pyrrolidine-2-carboxylic acid 1 ↔ 1 2 ↔ 5 3 ↔ 4 4 ↔ 3 5 ↔ 2 6 ↔ 6

NADH + L-1-Pyrroline-3-hydroxy-5-carboxylic acid = NAD+ + trans-4-Hydroxy-L-proline (links: NAD+ + (2S,4R) -4-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid = NADH + (2S,4R) -4-Hydroxypyrrolidine-2-carboxylic acid)

NAD+ <Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0 NADH 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32 (2S,4R) -4-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid <Mapping> AtomMap:BMMCHC--k023$BMACPLHO0010$0 (2S,4R) -4-Hydroxypyrrolidine-2-carboxylic acid 1 ↔ 1 2 ↔ 5 3 ↔ 4 4 ↔ 3 5 ↔ 2 6 ↔ 6