Index:PK

name	PKS	gene	organism	Ref	Size	C2	Image
1,3,8-Trihydroxyaceto-Naphthalene			Aspergillus parvulus	Herbert1989	12	6
1,3-Dihydroxy-N-Methylacridone	Acridone synthase			Dewick2009		3
3,8-Dihydroxy-1-Methylanthraquinone-2-Carboxylic Acid				Staunton&Weissman2001
4-Hydroxy-2-Quinolone				Dewick2009		1
5,7-Dihydroxy-2-Methylchromone	Pentaketide chromone synthase		Ammi visnaga	Dewick2009	10	5
5-Methylorsellinic Acid			Aspergillus flaviceps	Dewick2009	8	4
6-Deoxy-Erythronolide B	DEBS			Dewick2009
6-Methoxymellein				Dewick2009		5
6-Methyl Salicylic Acid	6-MSAS/P. patulum(ATX/Aspergillus terreus)	atX	Penicillium patulum, Aspergillus terreus	S. Gaisser, A. Trefzer, S. Stckert, A. Kirshning and A. Bechthold, J. Bacteriol., 1997, 179, 6271?6278.;Staunton&Weissman2001	8	4
Actinorhodin		act	Streptomyces coelicolor	Herbert1989	16	8
Adhyperforin			Hypericum perforatum	Dewick2009
Aflatoxin B1	PKSL1/Aspergillus parasiticus=PKSA	pksL1/Aspergillus parasiticus (Fas1,Fas2,PksA,Nor-1,AvnA, AdhA, AvfA, EstA,VBS, VerB,AflN,AflM,OmtB,OmtA,OrdA)	Aspergillus flavus, Aspergillus parasiticus	Staunton&Weissman2001;Yabe&Nakajima2004;Dewick2009	14	10
Aflatoxin B2			Aspergillus flavus, Aspergillus parasiticus	Dewick2009
Aflatoxin G1		(Fas1,Fas2,PksA,Nor-1,AvnA, AdhA, AvfA, EstA,VBS, VerB,AflN,AflM,OmtB,OmtA,OrdA)	Aspergillus flavus, Aspergillus parasiticus	Staunton&Weissman2001;Yabe&Nakajima2004;Dewick2009	11	10
Aflatoxin G2			Aspergillus flavus, Aspergillus parasiticus	Dewick2009
Aflatoxin M1			Aspergillus flavus, Aspergillus parasiticus	Dewick2009
Aloe-Emodin			Aloe ferox	Dewick2009;	15	8
Aloesaponarin II				Staunton&Weissman2001;Yabe&Nakajima2004;Dewick2009
Alternapyrone	PKSN	alt5 from Alternaria solani		2005,Fujii et al.An iterative type I polyketide synthase PKSN catalyzes synthesis of the decaketide alternapyrone with regio-specific octa-methylation.Chem Biol.	20	10
Alternaric Acid			Alternaria solani, Alternaria alternata (formerly known as A. kikuchiana)	Herbert1989	17	6
Alternariol			Alternaria tenuis	Herbert1989	14	7
Amphotericin B				Dewick2009
Andrimid
Aschochitin				Herbert1989			File:Aschochitin.Mol.png
Ascomycin				Dewick2009
Aslaniol		PKSF from A. solani		2009,Fujii.Heterologous expression systems for polyketide synthases.Nat Prod Rep.
Aslanipyrone		PKSF from A. solani		2009,Fujii.Heterologous expression systems for polyketide synthases.Nat Prod Rep.
Asperlactone			Aspergillus melleus	Herbert1989	8	5
Asperlin			Aspergillus nidulans	Herbert1989	8	5
Aspyridone A			Aspergillus nidulans	2007,Bergmann et al.Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans.Nat Chem Biol.;Challis2008
Aspyridone B				Challis2008
Aspyrone			Aspergillus melleus	Herbert1989	7	5
Asteltoxin			Aspergillus stellatus	Herbert1989 ;Kruger,G.J.,Steyn,P.S.,Vleggaar,R.,andRabie,C.J.(1979).X-raycrystalstructureofasteltoxin,anovelmycotoxinfrom Aspergillusstellatus Curzi.J.Chem.Soc.Chem.Commun. 441?442.		9
Astepyrone			Aspergillus terreus	Herbert1989		4
Atrochrysone			Penicillium sp, Aspergillus sp	Dewick2009;	15	8
Atrochrysone Aarboxylic Acid			Penicillium sp, Aspergillus sp	Dewick2009;	16	8	File:Atrochrysone Aarboxylic Acid.Mol.png
Aureothin			Streptomyces thioluteus	Herbert1989
Aurovertin			Streptomyces thioluteus				File:Aurovertin.Mol.png
Austdiol				Herbert1989 ;1983J. Chem. Soc., Chem. Commun_Evidence for a mono-oxygenase mechanism in the biosynthesis of austdiol		5
Avenaciolide				Herbert1989
Averantin		Nor-1;StcE	Aspergillus parasiticus, Aspergillus flavus	SanchezEtal2008;Dewick2009	20	10
Avermectin B1a				Dewick2009
Avermectin B2a				Dewick2009
Averufin		Fas1,Fas2,PksA,Nor-1,AvnA,AdhA	Aspergillus parasiticus, Aspergillus flavus	SanchezEtal2008;Dewick2009	20	10
Avilamycin				Dewick2009
Barnol			Penicillium baarnense	Herbert1989	9	4
Benzophenone			Penicillium griseofulvin	Dewick2009;Herbert1989	14	7
Bikaverin	Bikaverin nonaketide synthase	PKS4 from Gibberella fujikuroi	Gibberella fujikuroi	Herbert1989	18	9
Botryodiplodin				Herbert1989		4
Brefeldin A			Penicillium decumbens, Penicillium brefeldianum, Penicillium cyaneum, Aspergillus clavatus,Eupenicillium brefeldianum,	Herbert1989	16	8
Brevetoxin A			Karenia brevis	Dewick2009
Brevetoxin B			Karenia brevis	Dewick2009
C-1027
Calichemicin Gamma1			Micromonospora echinospora	2009,Belecki et al.Production of octaketide polyenes by the calicheamicin polyketide synthase CalE8: implications for the biosynthesis of enediyne core structures.J Am Chem Soc
Cannabidiol			Cannabis sativa (Indian hemp; Cannabaceae)	Dewick2009
Cannabigerolic Acid			Cannabis sativa (Indian hemp; Cannabaceae)	Dewick2009
Cannabinol			Cannabis sativa (Indian hemp; Cannabaceae)	Dewick2009
Cercosporin			Cercospora sp, Cercospora kikuchii	Herbert1989		7
Chlortetracycline	oxy PKS (otc)	OxyD,OxyA,OxyB,OxyC,OxyP,OxyJ,OxyK, OxyJ, OxyN,OxyI,OxyF,OxyL,OxyG,OxyQ,OxyR,OxyT,OxyS,OxyE,TchA	Streptomyces rimosus, Streptomyces aureofaciens	Dewick2009	19	8
Chrysomycin A			Streptomyces sp	Herbert1989	17	9
Chrysomycin B			Streptomyces sp	Herbert1989	17	9
Chrysophanol			Asahina chrysantha, Cassia angustifolia	Dewick2009;	15	8
Chrysophanol Anthrone			Asahina chrysantha, Cassia angustifolia	Dewick2009;	15	8
Ciguatoxin I			Gymnothorax javanicus, Lutjanus bohar	Dewick2009
Citreomontanin			Penicillium pedemontanum	1981,Sylvie Rebuffat, Daniel Davoust and Darius Molho, Phytochemistry, Biosynthesis of citreomontanin in Penicillium pedemontanum
Citreoviridin				Sakabe,N.,Goto,T.,andHirata,Y.(1977).Structureofcitreoviridin,amycotoxinproducedby Penicilliumcitreo-viride molded onrice.Tetrahedron 33,3077?3081.;Niwa,M.,Endo,T.,Ogiso,S.,Furukawa,H.,andYamamura,S. (1981).Twonewpyrones,metabolitesof Penicilliumcitreo-viride Biouge.Chem.Lett.(Jpn)1285?1288
Citrinin			Penicillium citrinum	Herbert1989	10	5
Clavatol			Aspergillus clavatus	Herbert1989	8	4
Coarctatin				Herbert1989	8	4
Colletodiol			Cytospora spp	Herbert1989 ;1993Biosynthesis of colletodiol and related polyketide macrodiolides in Cytospora sp. ATCC 20502 : synthesis and metabolism of advanced intermediates	8	7(4+3)
Compactin
Curvularin			Penicillium sp FP1768, Penicillium baradicum Hellllinrll Osporiulll	Herbert1989	16	8
Deoxyherquienone				Herbert1989	15	7
Deoxyradicin				Herbert1989	11	6
Dihydroisocoumarin			Aspergillus terreus	Herbert1989	10	5
Diplosporin			Diplodia macrospora	Herbert1989 ;1983, Charles P. Gorst-Allman, Pieter S. Steyn and Robert Vleggaar, Biosynthesis of diplosporin by Diplodia macrospora. Part 2. Investigation of ring formation using stable isotopes. J. Chem. Soc., Perkin Trans. 1,?1357 - 1359	10	5
Discodermolide				Dewick2009
Doramectin				Dewick2009
Dothistromin
Doxorubicin			Streptomyces peuceticus	Dewick2009
Emodin			Penicillium sp, Rhamnus sp, Rumex sp, Cassia angustifolia	Dewick2009;	15	8
Emodin Anthrone			Penicillium sp, Rhamnus sp, Rumex sp, Cassia angustifolia	Dewick2009;	15	8
Emodin Dianthrone				Dewick2009
Endocrocin			Penicillium sp, Rhamnus sp, Rumex sp, Cassia angustifolia	Dewick2009;	16	8
Endocrocin Anthrone			Penicillium sp, Rhamnus sp, Rumex sp, Cassia angustifolia	Dewick2009;	16	8
Enniatin B
Enterocin			Streptomyces maritimus
Epothilone A				Dewick2009
Epothilone B				Dewick2009
Epothilone C				Dewick2009
Epothilone D				Dewick2009
Epoxydon			Phyllosticta sp	Herbert1989 ;1975 Biosynthesis of Epoxydon and Related Compounds by Phyllosticta sp. Agric. Bioi. Chem. ( Japan), 39,409-13	7	4
Epsilon-Pyrromycinone				Herbert1989	20	9
Erythromycin				Dewick2009
Flavipin			Aspergillus flaviceps	Herbert1989	8	4
Fumigatin			Aspergillus fumigatus	Herbert1989	7	4
Fumonisin B1	FUM5		Fusarium verticillioides, Gibberella fujikuroi
Furanomycin				Herbert1989	7	3
Geldanamycin
Griseofulvin			Penicillium griseofulvin	Dewick2009;Herbert1989	14	7
Griseophenone B			Penicillium griseofulvin	Dewick2009;Herbert1989	14	7
Griseophenone C			Penicillium griseofulvin	Dewick2009;Herbert1989	14	7
Halichondrin B			Halichondria okadai	Dewick2009
Humulone			Humulus lululus (hop; Cannabaceae)	Dewick2009	13	3
Hyperforin			Hypericum perforatum	Dewick2009	17	3
Hypericin			Dermocybe spp	Dewick2009
Islandicin			Penicillium islandicum	Dewick2009;Herbert1989	15	8
Isoepoxydon			Penicillium patulum (=Penicillium urticae)
Isousnic Acid			Usnea spp, Cladonia spp	Dewick2009;Herbert1989	14	4
Ivermectin				Dewick2009
Khellin	Pentaketide chromone synthase		Ammi visnaga	Dewick2009	11	5
Lasalocid			Streptomyces lasaliensis	Dewick2009
Lecanoric Acid			Umbilicaria arctica, Umbilicaria nylanderiana	Dewick2009;Herbert1989	8	4
Leucomycin A1				Herbert1989
LL-D253alpha			Phoma pigmentivora	Herbert1989	11	6
Lovastatin	LOVB=LNKS, LovF=LDKS	loVF	Aspergillus terreus		yeast
M-Cresol			Aspergillus fumigatus	Dewick2009	7	4
Melanin	ALB1=PKSP,PKS1		Aspergillus fumigatus, Nodulisporium sp
Mellein			Aspergillus melleus, Aspergillus ochraceus	Herbert1989 ;2003_Natural Products_ the Secondary Metabolites (Tutorial Chemistry Texts)	10	5
Methylphloracetophenone			Usnea spp, Cladonia spp	Dewick2009;Herbert1989	8	4
Mollisin			Mollisia caesia	Herbert1989	11	8(8,3+5)
Monensin A			Streptomyces cinnamonensis	Herbert1989
Multicolic Acid			Penicillium multicolor	Herbert1989 ;1998,Application of Isotopic Methods to Secondary Metabolic Pathways. Thomas J.Simpson. Topics in Current Chemistry,Vol.195	10	6
Mycolactone			Mycobacterium ulcerans
Mycophenolic Acid			Penicillium brevicompactum	Dewick2009;Herbert1989	12	4
Myxalamide		MxaC-1	Stigmatella aurantiaca	2007,Pulsawat et al.Characterization of biosynthetic gene cluster for the production of virginiamycin M, a streptogramin type A antibiotic, in Streptomyces virginiae.Gene.
Myxothiazol A			Stigmatella aurantiaca
Myxothiazol Z			Stigmatella aurantiaca
Niddamycin			Streptomyces caelestis
Norsolorinic Acid	norsolorinic acid(NA) PKS	A?A/B(A.parasiticus); StcJ/K(A.nidulans)	Aspergillus parasiticus, Aspergillus flavus	SanchezEtal2008;Dewick2009	20	10
Nystatin			Streptomyces noursei	Dewick2009
Ochratoxin A		otapks of A. ochraceus; otapksPN gene from P. nordicum; ACpks from A. carbonarius	Aspergillus ochraceus, Penicillium viridicatum,Penicillium verrucosum, Penicillium nordicum, Aspergillus fumigatus, Aspergillus carbonarius	1979,Huff and Hamilton, W.E. Huff and P.B. Hamilton, Mycotoxins?their biosynthesis in fungi: ochratoxins?metabolites of combined pathways, Journal of Food Protection 42 (1979), pp. 815?820.;2001Harris and Mantle, J.P. Harris and P.G. Mantle, Biosynthesis of ochratoxins by Aspergillus ochraceus, Phytochemistry 58 (2001), pp. 709?716;2009,Gallo et al.Characterisation of a pks gene which is expressed during ochratoxin A production by Aspergillus carbonarius.Int J Food Microbiol.
Ochrephilone			Penicillium multicolor	Herbert1989	17	10(8+2)
Okadaic Acid			Dinophysis sp, Prorocentrum lima	Dewick2009
Oleandomycin			Streptomyces antibioticus	Dewick2009
Olivetolic Acid			Cannabis sativa (Indian hemp; Cannabaceae)	Dewick2009		4
O-Methylasparvenone			Aspergillus parvulus	Herbert1989 ; 1982, Application of?2H?-isotopic shifts in?13C n.m.r. spectra to biosynthetic studies. Incorporation of [1-13C,?2H3]acetate into?O-methylasparvenone in?Aspergillus parvulus. J. Chem. SOC., Chem. Commun.,1074.	12	6
Orcinol			Aspergillus fumigatus	Herbert1989	7	2
Orsellinic Acid	Orsellinic acid synthase (OSAS)	aviM	Streptomyces viridochromogenes, Penicillium madriti	Dewick2009;G.-L. Tang and W. Liu, Biochem. Biophys. Res. Commun., 2006,345, 133?139.	8	4
Oxytetracycline	oxy PKS (otc)	OxyD,OxyA,OxyB,OxyC,OxyP,OxyJ,OxyK, OxyJ, OxyN,OxyI,OxyF,OxyL,OxyG,OxyQ,OxyR,OxyT,OxyS,OxyE,TchA	Streptomyces rimosus, Streptomyces aureofaciens	Dewick2009	19	10
Palitantin			Penicillium palitans	Herbert1989	14	7
Patulin	MSAS;ATX(=MSAS)		Aspergillus clavatus,Aspergillus terreus,Penicillium patulum (=Penicillium urticae)	Dewick2009;1971,Aberhart and Caspi.The fate of the 6 alpha-hydrogen of 5 alpha-cholest-7-en-3 beta-ol in the conversion to 7-dehydrocholesterol by rat liver microsomes.J Biol Chem.	6	4
Penicillic Acid			Penicillium cyclopium, Penicillium baarnense	Herbert1989; Dewick2009	6	4
Phloracetophenone			Aspergillus clavatus		8	4
Phlorisobutyrophenone	Isobutyrophenonesynthase(BUS)		Hypericum calycinum	Dewick2009		3
Phlorisovalerophenone	phlorisovalerophenone synthase(VPS)		Humulus lululus (hop; Cannabaceae)	Dewick2009		3
Physcion			Penicillium sp, Rhamnus sp, Rumex sp, Cassia angustifolia	Dewick2009;	15	8
Picromycin			Streptomyces venezuelae	Herbert1989
Pimaricin
Platenomycin				Herbert1989			File:Platenomycin.Mol.png
Pretetramide	oxy PKS (otc)	OxyD,OxyA,OxyB,OxyC,OxyP,OxyJ,OxyK, OxyJ, OxyN,OxyI	Streptomyces rimosus,Streptomyces aureofaciens	Dewick2009	19	9
Protohypericin			Streptomyces natalensis	Dewick2009
Pyochelin			Pseudomonas aeruginosa
Pyoluteorin
Radicin				Herbert1989	11	6
Rapamycin			Streptomyces hygroscopicus	Dewick2009
Ravenilin			Helminthosporium ravenelii, Helminthosporium turcicum	Herbert1989	12	8
Rhein			Cassia angustifolia	2002,Dewick.Medicinal natural products : a biosynthetic approach.Wiley;Dewick2009;	15	8
Rifabutin				Dewick2009
Rifamycin B			Amycolatopsis mediterranei	Dewick2009
Rifapentine				Dewick2009
Rosellisin				Herbert1989	8	4
Rubrofusarin
Rubropunctatin			Monascus pilosus	Herbert1989	17	6
Sclerin			Sclerotinia spp	Herbert1989	9	5
Sclerotinin A			Sclerotinia spp	Herbert1989	10	5
SEK4	octaketide synthase OKS		Escherichia coli	Dewick2009	16	8
SEK4b	octaketide synthase OKS		Escherichia coli	Dewick2009	16	8
Selamectin				Dewick2009
Sennidin A			Cassia angustifolia, Cassia senna (syn Cassia acutifolia)	Dewick2009		8
Sennidin B			Cassia angustifolia, Cassia senna (syn Cassia acutifolia)	Dewick2009		8
Sennidin C			Cassia angustifolia, Cassia senna (syn Cassia acutifolia)	Dewick2009		8
Sennidin D			Cassia angustifolia, Cassia senna (syn Cassia acutifolia)	Dewick2009		8
Sennosides A			Cassia angustifolia, Cassia senna (syn Cassia acutifolia)	Dewick2009		8
Sennosides B			Cassia angustifolia, Cassia senna (syn Cassia acutifolia)	Dewick2009		8
Sennosides C			Cassia angustifolia, Cassia senna (syn Cassia acutifolia)	Dewick2009		8
Sennosides D			Cassia angustifolia, Cassia senna (syn Cassia acutifolia)	Dewick2009		8
Sepedonin						5
Siccanin			Helminthosporium siccans	Herbert1989
Silvaticamide			Aspergillus silvaticus	Herbert1989 ;1985 CPB_Biosynthesis of Silvaticamide, a Toxin from Aspergillus silvaticus	17	8(12)
SMA76a		pks4 from Gibberlla fujikuroi		Herbert1989	18	9
SMA76b		pks4 from Gibberlla fujikuroi		Herbert1989		9
SMA76c		pks4 from Gibberlla fujikuroi		Herbert1989		9
Soraphen A			Sorangium cellulosum
Spinulosin			Aspergillus fumigatus
Spiramycin I
Sterigmatocystin	NSAS,PKS-st(STCA)	Aspergillus nidulans(pksST)(stcA)(Fas1,Fas2,PksA,Nor-1,AvnA, AdhA, AvfA, EstA,VBS, VerB,AflN,AflM,OmtB)	Aspergillus parasiticus, Aspergillus flavus, Aspergillus nidulans	Yabe&Nakajima2004;Dewick2009;2009,Hertweck.The biosynthetic logic of polyketide diversity.Angew Chem Int Ed Engl.	15	10
Stigmatellin A			Stigmatella aurantiaca
Stipitatonic Acid			Penicillium stipitatum	Herbert1989 ;1963,Bentley.Biosynthesis of tropolones in Penicillium stipitatum.” J Biol Chem.	9	4
Sulochrin			Aspergillus terreus, Aspergillus fumigatus	Herbert1989	13	8
Tacrolimus			Streptomyces sp	Dewick2009
Tajixanthone			Aspergillus variecolor	Herbert1989	20	8(12)
Tennellin
Terrein			Aspergillus terreus, Aspergillus fumigatus	Herbert1989	8	5
Terrequinone A			Aspergillus nidulans	2007,Corre and Challis.Heavy tools for genome mining.Chem Biol.;[8]2007,Bouhired et al.Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA.Fungal Genet Biol.
Tetracenomycin F2		tcm	Streptomyces glaucescens	2008,Ames et al.Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides.Proc Natl Acad Sci U S A.
Tetracycline	oxy PKS (otc)	OxyD,OxyA,OxyB,OxyC,OxyP,OxyJ,OxyK, OxyJ, OxyN,OxyI,OxyF,OxyL,OxyG,OxyQ,OxyR,OxyT,OxyS,OxyE,TchA	Streptomyces rimosus,Streptomyces aureofaciens	Dewick2009	19	9
Tetrahydro Cannabinol			Cannabis sativa (Indian hemp; Cannabaceae)	Dewick2009
Tetrahydroxynaphthalene	tetrahydroxynaphthalene synthase (THNS);RppA	pks1, from Colletotrichum lagenarium	Streptomyces griseus, Streptomyces coelicolor, Colletotrichum lagenarium	2001,Pfeifer and Khosla.Biosynthesis of polyketides in heterologous hosts.Microbiol Mol Biol Rev.;2007,American Chemical Society. Meeting (229th : 2005 : San Diego Calif.) et al.Polyketides : biosynthesis, biological activity, and genetic engineering.American Chemical Society : Distributed by Oxford University Press	10	5
Triacetic Acid Lactone	2-pyrone synthase		Gerbera hybrida	2005BB_Microbial Synthesis of Triacetic Acid Lactone	6	3
Trypacidin			Aspergillus fumigatus
T-Toxin	PKS1		Cochliobolus heterostrophus
Tylactone			Streptomyces fradiae
Tylosin			Streptomyces fradiae	Dewick2009
Urushiol III			Toxicodendron radicans,Toxicodendron toxicaria	Dewick2009
Usnic Acid			Usnea spp, Cladonia spp, Flavocetraria cucculata, Flavocetraria nivalis	Dewick2009;	14(8,8)	8(4,4)
Variotin				Herbert1989	12	6
Versicolorin A		Fas1,Fas2,PksA,Nor-1,AvnA, AdhA, AvfA, EstA,VBS, VerB	Aspergillus parasiticus, Aspergillus flavus	Yabe&Nakajima2004;Dewick2009	17	10
Versicolorin B		Fas1,Fas2,PksA,Nor-1,AvnA, AdhA, AvfA, EstA,VBS	Aspergillus parasiticus, Aspergillus flavus	Yabe&Nakajima2004;Dewick2009	17	10
Versiconal		Fas1,Fas2,PksA,Nor-1,AvnA,AdhA,AvfA,EstA	Aspergillus parasiticus, Aspergillus flavus	Yabe&Nakajima2004;Dewick2009	17	10
Versiconal Acetate		Fas1,Fas2,PksA,Nor-1,AvnA,AdhA,AvfA	Aspergillus parasiticus, Aspergillus flavus	Yabe&Nakajima2004;Dewick2009	17	10
Visnagin	Pentaketide chromone synthase		Ammi visnaga	Dewick2009	11	5
WA-Naphthopyron		wA	Aspergillus nidulans
Zaragozic Acids A			Sporomiella intermedia, Leptodontium elatius
Zearalenone				Dewick2009