Enzyme:1.2.4.4

Revision as of 09:00, 2 February 2009

Upper Levels: EC1.-.-.- Oxidoreductases. : EC1.2.-.- Acting on the aldehyde or oxo group of donors. : EC1.2.4.- With a disulfide as acceptor.

3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase(decarboxylating, acceptor-2-methylpropanoylating)
Systematic Name	3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase(decarboxylating, acceptor-2-methylpropanoylating)
Common Name	3-methyl-2-oxobutanoate dehydrogenase(2-methylpropanoyl-transferring) 2-oxoisocaproate dehydrogenase 2-oxoisovalerate (lipoate) dehydrogenase 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylatingand acceptor-2-methylpropanoylating)

TPP + 3-Methyl-2-oxo-butanoic acid => 2-(2-Methyl-propanoyl)-thiamine diphosphate + CO2
(links: TPP + CO2 + 3-Methyl-2-oxo-butanoic acid = 2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-2-methylpropyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen phosphate + 3-Methyl-2-oxo-butanoic acid)

TPP	<Mapping> AtomMap:BMMCTZ--e012$BMMCTZ--e002$0	2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-2-methylpropyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen phosphate
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17

CO2	<Mapping> AtomMap:BMXXSX--0007$BMFYB4CAr010$0	3-Methyl-2-oxo-butanoic acid
	1 ↔ 1

3-Methyl-2-oxo-butanoic acid	<Mapping> AtomMap:BMFYB4CAr010$BMMCTZ--e002$0	2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-2-methylpropyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen phosphate
	2 ↔ 18 3 ↔ 19 4 ↔ 21 5 ↔ 20

TPP + 4-Methyl-2-oxo-pentanoic acid => 2-(3-Methyl-butanoyl)-thiamine diphosphate + CO2
(links: TPP + CO2 + 4-Methyl-2-oxo-pentanoic acid = 2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-3-methylbutyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen + 4-Methyl-2-oxo-pentanoic acid)

TPP	<Mapping> AtomMap:BMMCTZ--e012$BMMCTZ--e003$0	2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-3-methylbutyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17

CO2	<Mapping> AtomMap:BMXXSX--0007$BMFYB4CAr013$0	4-Methyl-2-oxo-pentanoic acid
	1 ↔ 1

4-Methyl-2-oxo-pentanoic acid	<Mapping> AtomMap:BMFYB4CAr013$BMMCTZ--e003$0	2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-3-methylbutyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen
	2 ↔ 18 3 ↔ 19 4 ↔ 20 5 ↔ 22 6 ↔ 21

2-(3-Methyl-butanoyl)-thiamine diphosphate + Lipoamide => TPP + S-(3-Methyl-butanoyl)-dihydro-lipoamide
(links: TPP + Lipoamide + 2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-3-methylbutyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen = 2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-3-methylbutyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen + S- (8-Amino-8-oxo-3-sulfanyloctyl) 3-methylbutanethioic acid)

TPP	<Mapping> AtomMap:BMMCTZ--e012$BMMCTZ--e003$0	2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-3-methylbutyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17

Lipoamide	<Mapping> AtomMap:BMMCHC--l024$BMFYB8AMf004$0	S- (8-Amino-8-oxo-3-sulfanyloctyl) 3-methylbutanethioic acid
	1 ↔ 10 2 ↔ 6 3 ↔ 7 4 ↔ 8 5 ↔ 9 6 ↔ 5 7 ↔ 4 8 ↔ 3 9 ↔ 2 10 ↔ 1 11 ↔ 11

2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-3-methylbutyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen	<Mapping> AtomMap:BMMCTZ--e003$BMFYB8AMf004$0	S- (8-Amino-8-oxo-3-sulfanyloctyl) 3-methylbutanethioic acid
	18 ↔ 12 19 ↔ 13 20 ↔ 14 21 ↔ 16 22 ↔ 15

2-((2S)-2-Methyl-butanoyl)-thiamine diphosphate + Lipoamide => TPP + S-(2-Methyl-butanoyl)-dihydro-lipoamide
(links: TPP + Lipoamide + 2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- [(2S) -1-hydroxy-2-methylbutyl] -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen phosphate = 2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- [(2S) -1-hydroxy-2-methylbutyl] -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen phosphate + S- (8-Amino-8-oxo-3-sulfanyloctyl) 2-methylbutanethioic acid)

TPP	<Mapping> AtomMap:BMMCTZ--e012$BMMCTZ--e001$0	2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- [(2S) -1-hydroxy-2-methylbutyl] -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen phosphate
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17

Lipoamide	<Mapping> AtomMap:BMMCHC--l024$BMFYB8AMf002$0	S- (8-Amino-8-oxo-3-sulfanyloctyl) 2-methylbutanethioic acid
	1 ↔ 10 2 ↔ 6 3 ↔ 7 4 ↔ 8 5 ↔ 9 6 ↔ 5 7 ↔ 4 8 ↔ 3 9 ↔ 2 10 ↔ 1 11 ↔ 11

2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- [(2S) -1-hydroxy-2-methylbutyl] -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen phosphate	<Mapping> AtomMap:BMMCTZ--e001$BMFYB8AMf002$0	S- (8-Amino-8-oxo-3-sulfanyloctyl) 2-methylbutanethioic acid
	18 ↔ 12 19 ↔ 13 20 ↔ 14 21 ↔ 15 22 ↔ 16

2-(2-Methyl-propanoyl)-thiamine diphosphate + Lipoamide => TPP + S-(2-Methyl-propanoyl)-dihydro-lipoamide
(links: TPP + Lipoamide + 2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-2-methylpropyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen phosphate = 2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-2-methylpropyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen phosphate + S- (8-Amino-8-oxo-3-sulfanyloctyl) 2-methylpropanethioic acid)

TPP	<Mapping> AtomMap:BMMCTZ--e012$BMMCTZ--e002$0	2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-2-methylpropyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen phosphate
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17

Lipoamide	<Mapping> AtomMap:BMMCHC--l024$BMFYB8AMf003$0	S- (8-Amino-8-oxo-3-sulfanyloctyl) 2-methylpropanethioic acid
	1 ↔ 11 2 ↔ 4 3 ↔ 3 4 ↔ 2 5 ↔ 1 6 ↔ 5 7 ↔ 6 8 ↔ 7 9 ↔ 8 10 ↔ 9 11 ↔ 10

2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-2-methylpropyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen phosphate	<Mapping> AtomMap:BMMCTZ--e002$BMFYB8AMf003$0	S- (8-Amino-8-oxo-3-sulfanyloctyl) 2-methylpropanethioic acid
	18 ↔ 12 19 ↔ 13 20 ↔ 15 21 ↔ 14

@@ Line 3: / Line 3: @@
 |SysName=3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase(decarboxylating, acceptor-2-methylpropanoylating)
 |names=&&3-methyl-2-oxobutanoate dehydrogenase(2-methylpropanoyl-transferring)&&2-oxoisocaproate dehydrogenase&&2-oxoisovalerate (lipoate) dehydrogenase&&3-methyl-2-oxobutanoate dehydrogenase (lipoamide)&&3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylatingand acceptor-2-methylpropanoylating)
+}}
+{{Enzyme/Reaction| reaction= TPP + 3-Methyl-2-oxo-butanoic acid => 2-(2-Methyl-propanoyl)-thiamine diphosphate + CO2
+| list=
+&& BMMCTZ--e012$BMMCTZ--e002$0
+&& BMXXSX--0007$BMFYB4CAr010$0
+&& BMFYB4CAr010$BMMCTZ--e002$0
+}}
+{{Enzyme/Reaction| reaction= TPP + 4-Methyl-2-oxo-pentanoic acid => 2-(3-Methyl-butanoyl)-thiamine diphosphate + CO2
+| list=
+&& BMMCTZ--e012$BMMCTZ--e003$0
+&& BMXXSX--0007$BMFYB4CAr013$0
+&& BMFYB4CAr013$BMMCTZ--e003$0
+}}
+{{Enzyme/Reaction| reaction= 2-(3-Methyl-butanoyl)-thiamine diphosphate + Lipoamide => TPP + S-(3-Methyl-butanoyl)-dihydro-lipoamide
+| list=
+&& BMMCTZ--e012$BMMCTZ--e003$0
+&& BMMCHC--l024$BMFYB8AMf004$0
+&& BMMCTZ--e003$BMFYB8AMf004$0
+}}
+{{Enzyme/Reaction| reaction= 2-((2S)-2-Methyl-butanoyl)-thiamine diphosphate + Lipoamide => TPP + S-(2-Methyl-butanoyl)-dihydro-lipoamide
+| list=
+&& BMMCTZ--e012$BMMCTZ--e001$0
+&& BMMCHC--l024$BMFYB8AMf002$0
+&& BMMCTZ--e001$BMFYB8AMf002$0
+}}
+{{Enzyme/Reaction| reaction= 2-(2-Methyl-propanoyl)-thiamine diphosphate + Lipoamide => TPP + S-(2-Methyl-propanoyl)-dihydro-lipoamide
+| list=
+&& BMMCTZ--e012$BMMCTZ--e002$0
+&& BMMCHC--l024$BMFYB8AMf003$0
+&& BMMCTZ--e002$BMFYB8AMf003$0
 }}

IDs and Links
IUBMB	EC1
ExPaSy	NiceZyme 1.2.4.4

Enzyme:1.2.4.4

Revision as of 09:00, 2 February 2009

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