Enzyme:1.2.1.51

Revision as of 09:00, 2 February 2009

pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)
Systematic Name	pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)
Common Name	pyruvate dehydrogenase (NADP+)

NADP+	<Mapping> AtomMap:BMCCPUAPt033$BMCCPUAPt034$0	NADPH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

CoA	<Mapping> AtomMap:BMCCPUAPf023$BMFYS2ESa001$0	S- [2- [3- [ [ (2R) -4- [ [ [ (2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] ethanethioate
	1 ↔ 4 2 ↔ 5 3 ↔ 6 4 ↔ 7 5 ↔ 8 6 ↔ 9 7 ↔ 10 8 ↔ 11 9 ↔ 12 10 ↔ 13 11 ↔ 14 12 ↔ 15 13 ↔ 16 14 ↔ 17 15 ↔ 18 32 ↔ 35 33 ↔ 36 34 ↔ 38 35 ↔ 37 36 ↔ 39 37 ↔ 40 38 ↔ 41 39 ↔ 42 40 ↔ 43 41 ↔ 44 42 ↔ 45 43 ↔ 46 44 ↔ 47 45 ↔ 48

CO2	<Mapping> AtomMap:BMXXSX--0007$BMFYS3CAp025$0	2-Oxo-propanoic acid
	1 ↔ 1

2-Oxo-propanoic acid	<Mapping> AtomMap:BMFYS3CAp025$BMFYS2ESa001$0	S- [2- [3- [ [ (2R) -4- [ [ [ (2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] ethanethioate
	2 ↔ 1 3 ↔ 2

NADP+ + CoA + 2-Oxo-butanoic acid = NADPH + Propanoyl-CoA + CO2
(links: NADP+ + CoA + CO2 + 2-Oxo-butanoic acid = NADPH + Propanoyl-CoA + 2-Oxo-butanoic acid)

NADP+	<Mapping> AtomMap:BMCCPUAPt033$BMCCPUAPt034$0	NADPH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

CoA	<Mapping> AtomMap:BMCCPUAPf023$BMFYS3ESa001$0	Propanoyl-CoA
	1 ↔ 5 2 ↔ 6 3 ↔ 7 4 ↔ 8 5 ↔ 9 6 ↔ 10 7 ↔ 11 8 ↔ 12 9 ↔ 13 10 ↔ 14 11 ↔ 15 12 ↔ 16 13 ↔ 17 14 ↔ 18 15 ↔ 19 32 ↔ 36 33 ↔ 37 34 ↔ 38 35 ↔ 39 36 ↔ 40 37 ↔ 41 38 ↔ 42 39 ↔ 43 40 ↔ 44 41 ↔ 45 42 ↔ 46 43 ↔ 47 44 ↔ 48 45 ↔ 49

CO2	<Mapping> AtomMap:BMXXSX--0007$BMFYS4CAp006$0	2-Oxo-butanoic acid
	1 ↔ 1

2-Oxo-butanoic acid	<Mapping> AtomMap:BMFYS4CAp006$BMFYS3ESa001$0	Propanoyl-CoA
	2 ↔ 1 3 ↔ 2 4 ↔ 3

@@ Line 3: / Line 3: @@
 |SysName=pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)
 |names=&&pyruvate dehydrogenase (NADP+)
+}}
+{{Enzyme/Reaction| reaction= NADP+ + CoA + Pyruvic acid = NADPH + Acetyl-CoA + CO2
+| list=
+&& BMCCPUAPt033$BMCCPUAPt034$0
+&& BMCCPUAPf023$BMFYS2ESa001$0
+&& BMXXSX--0007$BMFYS3CAp025$0
+&& BMFYS3CAp025$BMFYS2ESa001$0
+}}
+{{Enzyme/Reaction| reaction= NADP+ + CoA + 2-Oxo-butanoic acid = NADPH + Propanoyl-CoA + CO2
+| list=
+&& BMCCPUAPt033$BMCCPUAPt034$0
+&& BMCCPUAPf023$BMFYS3ESa001$0
+&& BMXXSX--0007$BMFYS4CAp006$0
+&& BMFYS4CAp006$BMFYS3ESa001$0
 }}

IDs and Links
IUBMB	EC1
ExPaSy	NiceZyme 1.2.1.51