Enzyme:2.5.1.48

Revision as of 09:00, 2 February 2009

O4-succinyl-L-homoserine:L-cysteineS-(3-amino-3-carboxypropyl)transferase
Systematic Name	O4-succinyl-L-homoserine:L-cysteineS-(3-amino-3-carboxypropyl)transferase
Common Name	cystathionine gamma-synthase O-succinyl-L-homoserine succinate-lyase (adding cysteine) O-succinylhomoserine (thiol)-lyase homoserine O-transsuccinylase O-succinylhomoserine synthase

O-Acetyl-L-serine + Thiosulfate = Acetic acid + S-Sulfo-L-cysteine
(links: O-Acetyl-L-serine + Sulfurothioic O-acid = Acetic acid + S-Sulfo-L-cysteine)

O-Acetyl-L-serine	<Mapping> AtomMap:BMAXS3HOi002$BMFYS2CA0001$0	Acetic acid
	5 ↔ 1 6 ↔ 2

Sulfurothioic O-acid	<Mapping> AtomMap:BMIOSF--0006$BMAAS3SF0008$0	S-Sulfo-L-cysteine
	2 ↔ 6 4 ↔ 5

O-Acetyl-L-serine	<Mapping> AtomMap:BMAXS3HOi002$BMAAS3SF0008$0	S-Sulfo-L-cysteine
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4

2-Oxo-butanoic acid	<Mapping> AtomMap:BMFYS4CAp006$BMAXS4ESj002$0	(2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4

Butanedioic acid	<Mapping> AtomMap:BMFYS4DA0015$BMAXS4ESj002$1 (2nd)	(2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid
	1 ↔ 9 2 ↔ 8 3 ↔ 7 4 ↔ 6

NH3	<Mapping> AtomMap:BMIONT--0004$BMAXS4ESj002$0	(2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid
	1 ↔ 5

(2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid	<Mapping> AtomMap:BMAXS4ESj002$BMFYS4DA0015$0	Butanedioic acid
	6 ↔ 4 7 ↔ 3 8 ↔ 2 9 ↔ 1

L-Cysteine	<Mapping> AtomMap:BMAAS3SF0003$BMFYB4CAf021$0	L-Cystathionine
	1 ↔ 7 2 ↔ 8 3 ↔ 9 4 ↔ 10 5 ↔ 6

(2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid	<Mapping> AtomMap:BMAXS4ESj002$BMFYB4CAf021$0	L-Cystathionine
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5

(2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid	<Mapping> AtomMap:BMAXS4ESj002$BMFYS4DA0015$0	Butanedioic acid
	6 ↔ 4 7 ↔ 3 8 ↔ 2 9 ↔ 1

Seleno-L-cysteine	<Mapping> AtomMap:BMAAS3MT0001$BMAXDP--c016$0	Seleno-L-cystathionine
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4

(2S) -2-Amino-4- (4-hydroxy-4-oxobutanoyl) oxybutanoic acid	<Mapping> AtomMap:BMAXS4ESj002$BMAXDP--c016$0	Seleno-L-cystathionine
	1 ↔ 5 2 ↔ 6 3 ↔ 7 4 ↔ 8 5 ↔ 9

O-Acetyl-L-homoserine + L-Cysteine = Acetic acid + L-Cystathionine
(links: O-Acetyl-L-homoserine + L-Cysteine = Acetic acid + L-Cystathionine)

O-Acetyl-L-homoserine	<Mapping> AtomMap:BMAXS4ESi001$BMFYS2CA0001$0	Acetic acid
	6 ↔ 1 7 ↔ 2

L-Cysteine	<Mapping> AtomMap:BMAAS3SF0003$BMFYB4CAf021$0	L-Cystathionine
	1 ↔ 7 2 ↔ 8 3 ↔ 9 4 ↔ 10 5 ↔ 6

O-Acetyl-L-homoserine	<Mapping> AtomMap:BMAXS4ESi001$BMFYB4CAf021$0	L-Cystathionine
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5

@@ Line 3: / Line 3: @@
 |SysName=O4-succinyl-L-homoserine:L-cysteineS-(3-amino-3-carboxypropyl)transferase
 |names=&&cystathionine gamma-synthase&&O-succinyl-L-homoserine succinate-lyase (adding cysteine)&&O-succinylhomoserine (thiol)-lyase&&homoserine O-transsuccinylase&&O-succinylhomoserine synthase
+}}
+{{Enzyme/Reaction| reaction= O-Acetyl-L-serine + Thiosulfate = Acetic acid + S-Sulfo-L-cysteine
+| list=
+&& BMAXS3HOi002$BMFYS2CA0001$0
+&& BMIOSF--0006$BMAAS3SF0008$0
+&& BMAXS3HOi002$BMAAS3SF0008$0
+}}
+{{Enzyme/Reaction| reaction= 2-Oxo-butanoic acid + Succinic acid + NH3 = O-Succinyl-L-homoserine + H2O
+| list=
+&& BMFYS4CAp006$BMAXS4ESj002$0
+&& BMFYS4DA0015$BMAXS4ESj002$1
+&& BMIONT--0004$BMAXS4ESj002$0
+}}
+{{Enzyme/Reaction| reaction= O-Succinyl-L-homoserine + L-Cysteine = Succinic acid + L-Cystathionine
+| list=
+&& BMAXS4ESj002$BMFYS4DA0015$0
+&& BMAAS3SF0003$BMFYB4CAf021$0
+&& BMAXS4ESj002$BMFYB4CAf021$0
+}}
+{{Enzyme/Reaction| reaction= O-Succinyl-L-homoserine + Seleno-L-cysteine = Succinic acid + Seleno-L-cystathionine
+| list=
+&& BMAXS4ESj002$BMFYS4DA0015$0
+&& BMAAS3MT0001$BMAXDP--c016$0
+&& BMAXS4ESj002$BMAXDP--c016$0
+}}
+{{Enzyme/Reaction| reaction= O-Acetyl-L-homoserine + L-Cysteine = Acetic acid + L-Cystathionine
+| list=
+&& BMAXS4ESi001$BMFYS2CA0001$0
+&& BMAAS3SF0003$BMFYB4CAf021$0
+&& BMAXS4ESi001$BMFYB4CAf021$0
 }}

IDs and Links
IUBMB	EC2
ExPaSy	NiceZyme 2.5.1.48