Enzyme:1.4.1.9

Revision as of 09:00, 2 February 2009

L-leucine:NAD+ oxidoreductase (deaminating)
Systematic Name	L-leucine:NAD+ oxidoreductase (deaminating)
Common Name	leucine dehydrogenase L-leucine:NAD+ oxidoreductase, deaminating LeuDH

NAD+ + L-Leucine + H2O => NADH + 4-Methyl-2-oxo-pentanoic acid + NH3
(links: NAD+ + (2S) -2-Amino-4-methylpentanoic acid = NADH + 4-Methyl-2-oxo-pentanoic acid + NH3)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

(2S) -2-Amino-4-methylpentanoic acid	<Mapping> AtomMap:BMAAB5AK0003$BMFYB4CAr013$0	4-Methyl-2-oxo-pentanoic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6

(2S) -2-Amino-4-methylpentanoic acid	<Mapping> AtomMap:BMAAB5AK0003$BMIONT--0004$0	NH3
	7 ↔ 1

NAD+ + L-Isoleucine + H2O => NADH + (R)-2-Oxo-3-methyl-pentanoic acid + NH3
(links: NAD+ + (2S) -2-Amino-3-methylpentanoic acid = NADH + (R) -2-Oxo-3-methyl-pentanoic acid + NH3)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

(2S) -2-Amino-3-methylpentanoic acid	<Mapping> AtomMap:BMAAB5AK0002$BMFYB5CAr003$0	(R) -2-Oxo-3-methyl-pentanoic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 7 ↔ 6

(2S) -2-Amino-3-methylpentanoic acid	<Mapping> AtomMap:BMAAB5AK0002$BMIONT--0004$0	NH3
	6 ↔ 1

NAD+ + L-Norleucine + H2O => NADH + 2-Oxo-hexanoic acid + NH3
(links: NAD+ + (2S) -2-Amino-hexanoic acid = NADH + 2-Oxo-hexanoic acid + NH3)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

(2S) -2-Amino-hexanoic acid	<Mapping> AtomMap:BMAXS6AK0001$BMFYS6CAp008$0	2-Oxo-hexanoic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6

(2S) -2-Amino-hexanoic acid	<Mapping> AtomMap:BMAXS6AK0001$BMIONT--0004$0	NH3
	7 ↔ 1

NAD+ + L-Norvaline + H2O => NADH + 2-Oxo-pentanoic acid + NH3
(links: NAD+ + L-Norvaline = NADH + 2-Oxo-pentanoic acid + NH3)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

L-Norvaline	<Mapping> AtomMap:BMAXS5AK0002$BMFYS5CAp009$0	2-Oxo-pentanoic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5

L-Norvaline	<Mapping> AtomMap:BMAXS5AK0002$BMIONT--0004$0	NH3
	6 ↔ 1

NAD+ + L-Valine + H2O => NADH + 3-Methyl-2-oxo-butanoic acid + NH3
(links: NAD+ + (2S) -2-Amino-3-methylbutanoic acid = NADH + 3-Methyl-2-oxo-butanoic acid + NH3)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

(2S) -2-Amino-3-methylbutanoic acid	<Mapping> AtomMap:BMAAB4AK0001$BMFYB4CAr010$0	3-Methyl-2-oxo-butanoic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5

(2S) -2-Amino-3-methylbutanoic acid	<Mapping> AtomMap:BMAAB4AK0001$BMIONT--0004$0	NH3
	6 ↔ 1

@@ Line 3: / Line 3: @@
 |SysName=L-leucine:NAD+ oxidoreductase (deaminating)
 |names=&&leucine dehydrogenase&&L-leucine:NAD+ oxidoreductase, deaminating&&LeuDH
+}}
+{{Enzyme/Reaction| reaction= NAD+ + L-Leucine + H2O => NADH + 4-Methyl-2-oxo-pentanoic acid + NH3
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMAAB5AK0003$BMFYB4CAr013$0
+&& BMAAB5AK0003$BMIONT--0004$0
+}}
+{{Enzyme/Reaction| reaction= NAD+ + L-Isoleucine + H2O => NADH + (R)-2-Oxo-3-methyl-pentanoic acid + NH3
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMAAB5AK0002$BMFYB5CAr003$0
+&& BMAAB5AK0002$BMIONT--0004$0
+}}
+{{Enzyme/Reaction| reaction= NAD+ + L-Norleucine + H2O => NADH + 2-Oxo-hexanoic acid + NH3
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMAXS6AK0001$BMFYS6CAp008$0
+&& BMAXS6AK0001$BMIONT--0004$0
+}}
+{{Enzyme/Reaction| reaction= NAD+ + L-Norvaline + H2O => NADH + 2-Oxo-pentanoic acid + NH3
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMAXS5AK0002$BMFYS5CAp009$0
+&& BMAXS5AK0002$BMIONT--0004$0
+}}
+{{Enzyme/Reaction| reaction= NAD+ + L-Valine + H2O => NADH + 3-Methyl-2-oxo-butanoic acid + NH3
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMAAB4AK0001$BMFYB4CAr010$0
+&& BMAAB4AK0001$BMIONT--0004$0
 }}

IDs and Links
IUBMB	EC1
ExPaSy	NiceZyme 1.4.1.9