Enzyme:1.2.4.1

Revision as of 09:00, 2 February 2009

pyruvate:[dihydrolipoyllysine-residueacetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating,acceptor-acetylating)
Systematic Name	pyruvate:[dihydrolipoyllysine-residueacetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating,acceptor-acetylating)
Common Name	pyruvate dehydrogenase (acetyl-transferring) MtPDC (mitochondrial pyruvate dehydogenase complex) pyruvate decarboxylase pyruvate dehydrogenase (lipoamide) pyruvate dehydrogenase complex

TPP + Pyruvic acid => 2-(Hydroxyethyl)-thiamine diphosphate + CO2
(links: TPP + CO2 + 2-Oxo-propanoic acid = 2- (Hydroxyethyl) -thiamine diphosphate + 2-Oxo-propanoic acid)

TPP	<Mapping> AtomMap:BMMCTZ--e012$BMMCTZ--e005$0	2- (Hydroxyethyl) -thiamine diphosphate
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17

CO2	<Mapping> AtomMap:BMXXSX--0007$BMFYS3CAp025$0	2-Oxo-propanoic acid
	1 ↔ 1

2-Oxo-propanoic acid	<Mapping> AtomMap:BMFYS3CAp025$BMMCTZ--e005$0	2- (Hydroxyethyl) -thiamine diphosphate
	2 ↔ 18 3 ↔ 19

TPP	<Mapping> AtomMap:BMMCTZ--e012$BMMCTZ--e005$0	2- (Hydroxyethyl) -thiamine diphosphate
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17

Lipoamide	<Mapping> AtomMap:BMMCHC--l024$BMFYB8AMf001$0	S- (8-Amino-8-oxo-1-sulfanyloctan-3-yl) ethanethioic acid
	1 ↔ 11 2 ↔ 6 3 ↔ 7 4 ↔ 8 5 ↔ 9 6 ↔ 5 7 ↔ 4 8 ↔ 3 9 ↔ 2 10 ↔ 1 11 ↔ 10

2- (Hydroxyethyl) -thiamine diphosphate	<Mapping> AtomMap:BMMCTZ--e005$BMFYB8AMf001$0	S- (8-Amino-8-oxo-1-sulfanyloctan-3-yl) ethanethioic acid
	18 ↔ 12 19 ↔ 13

@@ Line 3: / Line 3: @@
 |SysName=pyruvate:[dihydrolipoyllysine-residueacetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating,acceptor-acetylating)
 |names=&&pyruvate dehydrogenase (acetyl-transferring)&&MtPDC (mitochondrial pyruvate dehydogenase complex)&&pyruvate decarboxylase&&pyruvate dehydrogenase (lipoamide)&&pyruvate dehydrogenase complex
+}}
+{{Enzyme/Reaction| reaction= TPP + Pyruvic acid => 2-(Hydroxyethyl)-thiamine diphosphate + CO2
+| list=
+&& BMMCTZ--e012$BMMCTZ--e005$0
+&& BMXXSX--0007$BMFYS3CAp025$0
+&& BMFYS3CAp025$BMMCTZ--e005$0
+}}
+{{Enzyme/Reaction| reaction= 2-(Hydroxyethyl)-thiamine diphosphate + Lipoamide => TPP + 6-S-Acetyl-dihydro-lipoamide
+| list=
+&& BMMCTZ--e012$BMMCTZ--e005$0
+&& BMMCHC--l024$BMFYB8AMf001$0
+&& BMMCTZ--e005$BMFYB8AMf001$0
 }}

IDs and Links
IUBMB	EC1
ExPaSy	NiceZyme 1.2.4.1