Enzyme:1.2.4.2

Revision as of 09:00, 2 February 2009

2-oxoglutarate:[dihydrolipoyllysine-residuesuccinyltransferase]-lipoyllysine 2-oxidoreductase(decarboxylating, acceptor-succinylating)
Systematic Name	2-oxoglutarate:[dihydrolipoyllysine-residuesuccinyltransferase]-lipoyllysine 2-oxidoreductase(decarboxylating, acceptor-succinylating)
Common Name	oxoglutarate dehydrogenase (succinyl-transferring) 2-ketoglutarate dehydrogenase 2-oxoglutarate: lipoate oxidoreductase 2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating andacceptor-succinylating) alpha-ketoglutarate dehydrogenase

TPP + 2-Oxo-adipic acid = 2-(Glutaryl)-thiamine diphosphate + CO2
(links: TPP + CO2 + 2-Oxo-adipic acid = 2-Glutarylthiamine diphosphate + 2-Oxo-adipic acid)

TPP	<Mapping> AtomMap:BMMCTZ--e012$BMMCTZ--e004$0	2-Glutarylthiamine diphosphate
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17

CO2	<Mapping> AtomMap:BMXXSX--0007$BMFYS6DAp004$0	2-Oxo-adipic acid
	1 ↔ 1

2-Oxo-adipic acid	<Mapping> AtomMap:BMFYS6DAp004$BMMCTZ--e004$0	2-Glutarylthiamine diphosphate
	2 ↔ 18 3 ↔ 19 4 ↔ 20 5 ↔ 21 6 ↔ 22

TPP	<Mapping> AtomMap:BMMCTZ--e012$BMMCTZ--e006$0	4- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -5- [2- [hydroxy (phosphonooxy) phosphoryl] oxyethyl] -4-methyl-1,3-thiazol-3-ium-2-yl] -4-hydroxybutanoic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17

Lipoamide	<Mapping> AtomMap:BMMCHC--l024$BMFYB8AMf006$0	4- (8-Amino-8-oxo-3-sulfanyloctyl) sulfanyl-4-oxobutanoic acid
	1 ↔ 10 2 ↔ 6 3 ↔ 7 4 ↔ 8 5 ↔ 9 6 ↔ 5 7 ↔ 4 8 ↔ 3 9 ↔ 2 10 ↔ 1 11 ↔ 15

4- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -5- [2- [hydroxy (phosphonooxy) phosphoryl] oxyethyl] -4-methyl-1,3-thiazol-3-ium-2-yl] -4-hydroxybutanoic acid	<Mapping> AtomMap:BMMCTZ--e006$BMFYB8AMf006$0	4- (8-Amino-8-oxo-3-sulfanyloctyl) sulfanyl-4-oxobutanoic acid
	18 ↔ 14 19 ↔ 13 20 ↔ 12 21 ↔ 11

TPP	<Mapping> AtomMap:BMMCTZ--e012$BMMCTZ--e006$0	4- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -5- [2- [hydroxy (phosphonooxy) phosphoryl] oxyethyl] -4-methyl-1,3-thiazol-3-ium-2-yl] -4-hydroxybutanoic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17

CO2	<Mapping> AtomMap:BMXXSX--0007$BMFYS5DAp005$0	2-Oxo-pentanedioic acid
	1 ↔ 1

2-Oxo-pentanedioic acid	<Mapping> AtomMap:BMFYS5DAp005$BMMCTZ--e006$0	4- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -5- [2- [hydroxy (phosphonooxy) phosphoryl] oxyethyl] -4-methyl-1,3-thiazol-3-ium-2-yl] -4-hydroxybutanoic acid
	2 ↔ 21 3 ↔ 20 4 ↔ 19 5 ↔ 18

TPP	<Mapping> AtomMap:BMMCTZ--e012$BMMCTZ--e004$0	2-Glutarylthiamine diphosphate
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17

Lipoamide	<Mapping> AtomMap:BMMCHC--l024$BMFYB8AMf005$0	5- (8-Amino-8-oxo-3-sulfanyloctyl) sulfanyl-5-oxopentanoic acid
	1 ↔ 10 2 ↔ 4 3 ↔ 3 4 ↔ 2 5 ↔ 1 6 ↔ 5 7 ↔ 6 8 ↔ 7 9 ↔ 8 10 ↔ 9 11 ↔ 11

2-Glutarylthiamine diphosphate	<Mapping> AtomMap:BMMCTZ--e004$BMFYB8AMf005$0	5- (8-Amino-8-oxo-3-sulfanyloctyl) sulfanyl-5-oxopentanoic acid
	18 ↔ 16 19 ↔ 15 20 ↔ 14 21 ↔ 13 22 ↔ 12

@@ Line 3: / Line 3: @@
 |SysName=2-oxoglutarate:[dihydrolipoyllysine-residuesuccinyltransferase]-lipoyllysine 2-oxidoreductase(decarboxylating, acceptor-succinylating)
 |names=&&oxoglutarate dehydrogenase (succinyl-transferring)&&2-ketoglutarate dehydrogenase&&2-oxoglutarate: lipoate oxidoreductase&&2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating andacceptor-succinylating)&&alpha-ketoglutarate dehydrogenase
+}}
+{{Enzyme/Reaction| reaction= TPP + 2-Oxo-adipic acid = 2-(Glutaryl)-thiamine diphosphate + CO2
+| list=
+&& BMMCTZ--e012$BMMCTZ--e004$0
+&& BMXXSX--0007$BMFYS6DAp004$0
+&& BMFYS6DAp004$BMMCTZ--e004$0
+}}
+{{Enzyme/Reaction| reaction= 2-(Succinyl)-thiamine diphosphate + Lipoamide = TPP + S-Succinyl-dihydro-lipoamide
+| list=
+&& BMMCTZ--e012$BMMCTZ--e006$0
+&& BMMCHC--l024$BMFYB8AMf006$0
+&& BMMCTZ--e006$BMFYB8AMf006$0
+}}
+{{Enzyme/Reaction| reaction= TPP + 2-Oxo-glutaric acid = 2-(Succinyl)-thiamine diphosphate + CO2
+| list=
+&& BMMCTZ--e012$BMMCTZ--e006$0
+&& BMXXSX--0007$BMFYS5DAp005$0
+&& BMFYS5DAp005$BMMCTZ--e006$0
+}}
+{{Enzyme/Reaction| reaction= 2-(Glutaryl)-thiamine diphosphate + Lipoamide = TPP + S-Glutaryl-dihydro-lipoamide
+| list=
+&& BMMCTZ--e012$BMMCTZ--e004$0
+&& BMMCHC--l024$BMFYB8AMf005$0
+&& BMMCTZ--e004$BMFYB8AMf005$0
 }}

IDs and Links
IUBMB	EC1
ExPaSy	NiceZyme 1.2.4.2