Enzyme:1.1.1.35

Revision as of 09:00, 2 February 2009

Upper Levels: EC1.-.-.- Oxidoreductases. : EC1.1.-.- Acting on the CH-OH group of donors. : EC1.1.1.- With NAD(+) or NADP(+) as acceptor.

(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
Systematic Name	(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
Common Name	3-hydroxyacyl-CoA dehydrogenase beta-hydroxyacyl dehydrogenase beta-keto-reductase 3-hydroxyacyl coenzyme A dehydrogenase beta-hydroxyacyl-coenzyme A synthetase

NAD+ + (S)-3-Hydroxy-2-methyl-propanoic acid = NADH + (S)-Methyl-malonate semialdehyde
(links: NAD+ + (2S) - 2-Methyl-3-oxopropanoic acid = NADH + (2S) -3-Hydroxy-2-methylpropanoic acid)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

(2S) - 2-Methyl-3-oxopropanoic acid	<Mapping> AtomMap:BMFYB3SAr001$BMFYB3CAr006$0	(2S) -3-Hydroxy-2-methylpropanoic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4

NAD+ + (S)-3-Hydroxy-butanoyl-CoA = NADH + Acetoacetyl-CoA
(links: NAD+ + S- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] (3S) -3-hydroxybutanethioic acid = NADH + S- [2- [3- [ [ (2R) -4- [ [ [ (2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] 3-oxobutanethioate)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

S- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] (3S) -3-hydroxybutanethioic acid	<Mapping> AtomMap:BMFYS4ESa002$BMFYS4ESa004$0	S- [2- [3- [ [ (2R) -4- [ [ [ (2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] 3-oxobutanethioate
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17 18 ↔ 18 19 ↔ 19 20 ↔ 20 21 ↔ 21 38 ↔ 38 39 ↔ 39 40 ↔ 41 41 ↔ 40 42 ↔ 42 43 ↔ 43 44 ↔ 44 45 ↔ 45 46 ↔ 46 47 ↔ 47 48 ↔ 48 49 ↔ 49 50 ↔ 50 51 ↔ 51

NAD+ + (Hydroxy-methyl-phenyl)-succinyl-CoA = NADH + Benzoyl-succinyl-CoA
(links: NAD+ + (3R,4R) -3- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethylsulfanylcarbonyl] -4-hydroxy-4-phenylbutanoic acid = NADH + (3R) -3- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethylsulfanylcarbonyl] -4-oxo-4-phenylbutanoic acid)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

(3R,4R) -3- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethylsulfanylcarbonyl] -4-hydroxy-4-phenylbutanoic acid	<Mapping> AtomMap:BMMCBZ1Sa001$BMMCBZ1Sa018$0	(3R) -3- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethylsulfanylcarbonyl] -4-oxo-4-phenylbutanoic acid
	1 ↔ 4 2 ↔ 3 3 ↔ 2 4 ↔ 1 5 ↔ 5 6 ↔ 6 7 ↔ 11 8 ↔ 10 9 ↔ 9 10 ↔ 8 11 ↔ 7 16 ↔ 16 17 ↔ 17 18 ↔ 18 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 27 ↔ 27 28 ↔ 28 29 ↔ 29 30 ↔ 30 47 ↔ 47 48 ↔ 48 49 ↔ 50 50 ↔ 49 51 ↔ 51 52 ↔ 52 53 ↔ 53 54 ↔ 54 55 ↔ 55 56 ↔ 56 57 ↔ 57 58 ↔ 58 59 ↔ 59 60 ↔ 60

NAD+ + (S)-3-Hydroxy-hexanoyl-CoA = NADH + 3-Oxo-hexanoyl-CoA
(links: NAD+ + S- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] (3S) -3-hydroxyhexanethioic acid = NADH + 3-Oxo-hexanoyl-CoA)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

S- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] (3S) -3-hydroxyhexanethioic acid	<Mapping> AtomMap:BMFYS6ESa001$BMFYS6ESa002$0	3-Oxo-hexanoyl-CoA
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17 18 ↔ 18 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 40 ↔ 40 41 ↔ 41 42 ↔ 43 43 ↔ 42 44 ↔ 44 45 ↔ 45 46 ↔ 46 47 ↔ 47 48 ↔ 48 49 ↔ 49 50 ↔ 50 51 ↔ 51 52 ↔ 52 53 ↔ 53

NAD+ + (S)-3-Hydroxy-octanoyl-CoA = NADH + 3-Oxo-octanoyl-CoA
(links: NAD+ + (S) -3-Hydroxy-octanoyl-CoA = NADH + 3-Oxo-octanoyl-CoA)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

(S) -3-Hydroxy-octanoyl-CoA	<Mapping> AtomMap:BMFYS8ESa001$BMFYS8ESa002$0	3-Oxo-octanoyl-CoA
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17 18 ↔ 18 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 42 ↔ 42 43 ↔ 43 44 ↔ 45 45 ↔ 44 46 ↔ 46 47 ↔ 47 48 ↔ 48 49 ↔ 49 50 ↔ 50 51 ↔ 51 52 ↔ 52 53 ↔ 53 54 ↔ 54 55 ↔ 55

NAD+ + (S)-3-Hydroxy-2-methyl-butanoyl-CoA = NADH + 2-Methyl-3-acetoacetyl-CoA
(links: NAD+ + S- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] (2S,3S) -3-hydroxy-2-methylbutanethioic acid = NADH + S- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino]propanoylamino] ethyl] 2-methyl-3-oxobutanethioic acid)

NAD+	<Mapping> AtomMap:BMCCPUAPt031$BMCCPUAPt032$0	NADH
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32

S- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] (2S,3S) -3-hydroxy-2-methylbutanethioic acid	<Mapping> AtomMap:BMFYB4ESa001$BMFYB4ESa002$0	S- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino]propanoylamino] ethyl] 2-methyl-3-oxobutanethioic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 5 5 ↔ 4 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17 18 ↔ 18 19 ↔ 19 20 ↔ 20 21 ↔ 21 22 ↔ 22 39 ↔ 39 40 ↔ 40 41 ↔ 42 42 ↔ 41 43 ↔ 43 44 ↔ 44 45 ↔ 45 46 ↔ 46 47 ↔ 47 48 ↔ 48 49 ↔ 49 50 ↔ 50 51 ↔ 51 52 ↔ 52

@@ Line 3: / Line 3: @@
 |SysName=(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
 |names=&&3-hydroxyacyl-CoA dehydrogenase&&beta-hydroxyacyl dehydrogenase&&beta-keto-reductase&&3-hydroxyacyl coenzyme A dehydrogenase&&beta-hydroxyacyl-coenzyme A synthetase
+}}
+{{Enzyme/Reaction| reaction= NAD+ + (S)-3-Hydroxy-2-methyl-propanoic acid = NADH + (S)-Methyl-malonate semialdehyde
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMFYB3SAr001$BMFYB3CAr006$0
+}}
+{{Enzyme/Reaction| reaction= NAD+ + (S)-3-Hydroxy-butanoyl-CoA = NADH + Acetoacetyl-CoA
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMFYS4ESa002$BMFYS4ESa004$0
+}}
+{{Enzyme/Reaction| reaction= NAD+ + (Hydroxy-methyl-phenyl)-succinyl-CoA = NADH + Benzoyl-succinyl-CoA
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMMCBZ1Sa001$BMMCBZ1Sa018$0
+}}
+{{Enzyme/Reaction| reaction= NAD+ + (S)-3-Hydroxy-hexanoyl-CoA = NADH + 3-Oxo-hexanoyl-CoA
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMFYS6ESa001$BMFYS6ESa002$0
+}}
+{{Enzyme/Reaction| reaction= NAD+ + (S)-3-Hydroxy-octanoyl-CoA = NADH + 3-Oxo-octanoyl-CoA
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMFYS8ESa001$BMFYS8ESa002$0
+}}
+{{Enzyme/Reaction| reaction= NAD+ + (S)-3-Hydroxy-2-methyl-butanoyl-CoA = NADH + 2-Methyl-3-acetoacetyl-CoA
+| list=
+&& BMCCPUAPt031$BMCCPUAPt032$0
+&& BMFYB4ESa001$BMFYB4ESa002$0
 }}

IDs and Links
IUBMB	EC1
ExPaSy	NiceZyme 1.1.1.35

Enzyme:1.1.1.35

Revision as of 09:00, 2 February 2009

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