Doc:FL63AC

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Catechins refer to a subgroup of flavan 3-ol derivatives (FL63AC). The two chiral center at C2 and C3 of the flavan 3-ols produces 4 isomers, and (+)-Catechin and its stereoisomer (-)-Epicatechin are naturally abundant. Less abundant are (-)-Catechin and (+)-Epicatechin.

  • afzelechin ... catechin minus 1 hydroxyl group in ring B
  • gallocatechin ... catechin plus 1 hydroxyl group in ring B

Structure FL63ACNS0001.png FL63ACNS0002.png FL63ACNS0004.png FL63ACNS0003.png
Name (+)-Catechin or
D-Catechin
(-)-Epicatechin or
L-Epicatechin
ent-Catechin or
(-)-Catechin
ent-Epicatechin or
(+)-Epicatechin
B-ring stereo
3-Hydroxyl stereo
Afzelechins (+)-Afzelechin (-)-Epiafzelechin ent-Epiafzelechin
Gallocatechins (+)-Gallocatechin (-)-Epigallocatechin ent-Gallocatechin

Among the stereoisomers, the bioavailability in human follows the order:

(-)-epicatechin > (+)-catechin = (+)-epicatechin > (-)-catechin

The circulation level of (-)-epicatechin is 6 times higher than that of (-)-catechin. Naturally abundant species are more bioavailable than less abundant ones.

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