Doc:Bioactives - Revision history

Adm: /* {{Bilingual|アクチノミセス目では、珍しい種が多くの変わった物質を生産する。|In actinomycetales, the rare actinos produce most diverse and unique compounds.}} */

2011-06-06T05:45:49Z

‎{{Bilingual|アクチノミセス目では、珍しい種が多くの変わった物質を生産する。|In actinomycetales, the rare actinos produce most diverse and unique compounds.}}

Adm at 05:43, 6 June 2011

2011-06-06T05:43:23Z

Adm at 02:27, 24 September 2010

2010-09-24T02:27:26Z

Adm: /* {{Bilingual|アクチノミセス目では、珍しい種が多くの変わった物質を生産する。|In actinomycetales, the rare actinos produce most diverse and unique compounds.}} */

2010-09-24T02:03:41Z

‎{{Bilingual|アクチノミセス目では、珍しい種が多くの変わった物質を生産する。|In actinomycetales, the rare actinos produce most diverse and unique compounds.}}

Adm at 04:42, 23 September 2010

2010-09-23T04:42:39Z

Adm: /* {{Bilingual|生理活性とは|On Bioactivity}} */

2010-09-23T04:40:59Z

‎{{Bilingual|生理活性とは|On Bioactivity}}

Adm at 03:55, 23 September 2010

2010-09-23T03:55:12Z

Adm at 08:39, 22 September 2010

2010-09-22T08:39:26Z

Show changes

Adm at 08:11, 22 September 2010

2010-09-22T08:11:33Z

Adm: New page: =={{Bilingual|生理活性物質|Bioactive Metabolites}}== {| class="wikitable" style="text-align:center" |+ Table 1 Approximate number of known natural productsBerdy J ...

2010-09-22T07:44:32Z

New page: =={{Bilingual|生理活性物質|Bioactive Metabolites}}== {| class="wikitable" style="text-align:center" |+ Table 1 Approximate number of known natural products<ref name="Berdy">Berdy J ...

New page

=={{Bilingual|生理活性物質|Bioactive Metabolites}}==

{| class="wikitable" style="text-align:center"
|+ Table 1 Approximate number of known natural products<ref name="Berdy">Berdy J (2005) "Bioactive Microbial Metabolites" ''J Antibiot'' 58(1):1-26</ref>
! style="text-align:left" | Source
! All known compounds || “Bioactives”|| Antibiotics
|-
|style="text-align:left" | Natural Products || over one million || 200000 to 250000 || 25000 to 30000
|-
|style="text-align:left" | Plant Kingdom || 600000 to 700000 || 150000 to 200000 || ca. 25000
|-
|style="text-align:left" |   Microbes || over 50000 || 22000 to 23000 || ca. 17000
|-
|style="text-align:left" |   Algae, Lichens || 3000 to 5000 || 1500 to 2000 || ca. 1000
|-
|style="text-align:left" |   Higher Plants || 500000 to 600000 || ca. 100000 || 10000 to 12000
|-
|style="text-align:left" | Animal Kingdom || 300000 to 400000 || 50000 to 100000 || ca. 5000
|-
|style="text-align:left" |   Protozoa || several hundreds || 100 to 200 || ca. 50
|-
|style="text-align:left" |   Invertebrates: || ca. 100000 || ? || ca. 500
|-
|style="text-align:left" |     Marine animals || 20000 to 25000 || 7000 to 8000 || 3000 to 4000
|-
|style="text-align:left" |     Insects/worms/etc. || 8000 to 10000 || 800 to 1000 || 150 to 200
|-
|style="text-align:left" | Vertebrates<br/>(mammals, fishes, amphibians, etc.) || 200000 to 250000 || 50000 to 70000 || ca. 1000
|}

@@ Line 236: / Line 236: @@
 |}
-=={{Bilingual|アクチノミセス目では、珍しい種が多くの変わった物質を生産する。|In actinomycetales, the rare actinos produce most diverse and unique compounds.}}==
+=={{Bilingual|放線菌類では、珍しい種が多くの変わった物質を生産する。|In actinomycetales, the rare actinos produce most diverse and unique compounds.}}==
 {{Twocolumn|
@@ Line 249: / Line 249: @@
 are produced exclusively by actinomycetales.
+|
-; 希少アクチノマイセス属特有
+; 希少アクチノマイセス（放線菌類）属特有
 * 知られる全ての糖ペプチド抗生物質（およそ120)とほぼ全てのオルトソマイシンは、希少アクチノマイセス属由来。
 ; アクチノマイセス目特有

← Older revision		Revision as of 05:43, 6 June 2011
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		+	{{#def:LANG\|{{#getenv:LANG}}}}
		+
	=={{Bilingual\|生理活性物質\|Bioactive Metabolites}}==		=={{Bilingual\|生理活性物質\|Bioactive Metabolites}}==
	{{Twocolumn\|		{{Twocolumn\|

@@ Line 1: / Line 1: @@
 =={{Bilingual|生理活性物質|Bioactive Metabolites}}==
 {{Twocolumn|
 Bioactivity refers to antimicrobial, antitumor, antiviral, pharmacological, and similar activities. Such functions are generally not associated with structures or producer species or pathways.
@@ Line 73: / Line 71: @@
 |}
-==={{Bilingual|生理活性物質は自然界に20～25万程度存在すると予想される。|The number of bioactive natural products is estimated around 200000 to 250000.}}===
+=={{Bilingual|生理活性物質は自然界に20～25万程度存在すると予想される。|The number of bioactive natural products is estimated around 200000 to 250000.}}==
 Approximate number of known natural products<ref name="Berdy"/>
 {| class="wikitable" style="text-align:center"
@@ Line 102: / Line 100: @@
 |}
-==={{Bilingual|微生物の中では、放線菌とカビ類が生理活性物質を生産する。|In microbes, most bioactive natural products are found in Actinomycetales and fungi.}}===
+=={{Bilingual|微生物の中では、放線菌とカビ類が生理活性物質を生産する。|In microbes, most bioactive natural products are found in Actinomycetales and fungi.}}==
 Approximate number of bioactive microbial natural products (2002). According to their producers<ref name="Berdy"/>
 {| class="wikitable" style="text-align:center"
@@ Line 116: / Line 114: @@
 |}
-==={{Bilingual|高等生物の中では、植物と海綿類が生理活性物質を生産する。|In higher forms of life, most natural products are found in plants and sponges.}}===
+=={{Bilingual|高等生物の中では、植物と海綿類が生理活性物質を生産する。|In higher forms of life, most natural products are found in plants and sponges.}}==
 Approximate numbers of bioactive natural products (2002). Derived from higher forms of life<ref name="Berdy"/>
 {| class="wikitable" style="text-align:center"
@@ Line 167: / Line 165: @@
 |}
-==={{Bilingual|微生物の中でも、生理活性物質を生産する種は限られる。|Most frequent producers are relatively limited.}}===
+=={{Bilingual|微生物の中でも、生理活性物質を生産する種は限られる。|Most frequent producers are relatively limited.}}==
 Approximate number of bioactive microbial metabolites according to their producers and bioactivities<ref name="Berdy"/>
 {| class="wikitable" style="text-align:center"
@@ Line 214: / Line 234: @@
 |}
-==={{Bilingual|アクチノミセス目では、珍しい種が多くの変わった物質を生産する。|In actinomycetales, the rare actinos produce most diverse and unique compounds.}}===
+=={{Bilingual|アクチノミセス目では、珍しい種が多くの変わった物質を生産する。|In actinomycetales, the rare actinos produce most diverse and unique compounds.}}==
 {{Twocolumn|
@@ Line 226: / Line 246: @@
 :: elfamycins, glutarimides, orthosomycins (50-60 each)
 are produced exclusively by actinomycetales.
+|
 ; 希少アクチノマイセス属特有

@@ Line 215: / Line 215: @@
 ==={{Bilingual|アクチノミセス目では、珍しい種が多くの変わった物質を生産する。|In actinomycetales, the rare actinos produce most diverse and unique compounds.}}===
 Number of actinomycetales species producing bioactive microbial metabolites<ref name="Berdy"/>
 {|

@@ Line 10: / Line 10: @@
 {|
-! colspan="2" | Bioactivity types of discovered microbial metabolites
+! colspan="2" | Bioactivity types of discovered microbial metabolites <ref name="Berdy">Berdy J (2005) "Bioactive Microbial Metabolites" ''J Antibiot'' 58(1):1-26</ref>
 |-
 | valign="top" |
@@ Line 74: / Line 74: @@
 ==={{Bilingual|生理活性物質は自然界に20～25万程度存在すると予想される。|The number of bioactive natural products is estimated around 200000 to 250000.}}===
-Approximate number of known natural products<ref name="Berdy">Berdy J (2005) "Bioactive Microbial Metabolites" ''J Antibiot'' 58(1):1-26</ref>
+Approximate number of known natural products<ref name="Berdy"/>
 {| class="wikitable" style="text-align:center"
 ! style="text-align:left" | Source
@@ Line 355: / Line 355: @@
 |}
 |}

@@ Line 8: / Line 8: @@
 }}
 {| class="wikitable"
-!Antibiotic activity || Other bioactivities
+! colspan="3" | Antibiotic Activity (16500 compounds)
 |-
+| biophysical effects (surfactants, etc.) || -300
-* Antimicrobial
+|}
-** Antibacterial
-*** Gram-positive
-*** Gram-negative
-*** Mycobacteria
-** Antifungal
-*** Yeasts
-*** Phytopathogenic fungi
-*** Others
-** Antiprotozoal
-* Chemotherapeutic
-*** Antitumor
-*** Antiviral
-−
-* Pharmacological
-** enzyme inhibitor
-** immunological activity
-** biochemical activity
-** others
-* Agricultural
-** pesticide
-** herbicide
-** insecticide/miticide/larvicide/deterrent
-** feed additive, preservative
-* Others
-** growth factors, hormones, morphogens
-** surfactants, etc.
 |}

@@ Line 7: / Line 7: @@
 生理活性とは、抗菌、抗腫瘍、抗ウィルス、そして薬に類する機能を指しています。こうした機能は通常、化学構造や生産する生物種や生合成経路とは関連がありません。
 }}
 ==={{Bilingual|生理活性物質は自然界に20～25万程度存在すると予想される。|The number of bioactive natural products is estimated around 200000 to 250000.}}===